Low Platelet to White Blood Cell Ratio Indicates Poor Prognosis for Acute-On-Chronic Liver Failure
المؤلفون المشاركون
Jie, Yusheng
Chong, Yutian
Gong, Jiao
Xiao, Cuicui
Zhu, Shuguang
Zhou, Wenying
Luo, Juan
Hu, Bo
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-05-08
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background.
Platelet to white blood cell ratio (PWR) was an independent prognostic predictor for outcomes in some diseases.
However, the prognostic role of PWR is still unclear in patients with hepatitis B related acute-on-chronic liver failure (ACLF).
In this study, we evaluated the clinical performances of PWR in predicting prognosis in HBV-related ACLF.
Methods.
A total of 530 subjects were recruited, including 97 healthy controls and 433 with HBV-related ACLF.
Liver function, prothrombin time activity (PTA), international normalized ratio (INR), HBV DNA measurement, and routine hematological testing were performed at admission.
Results.
At baseline, PWR in patients with HBV-related ACLF (14.03 ± 7.17) was significantly decreased compared to those in healthy controls (39.16 ± 9.80).
Reduced PWR values were clinically associated with the severity of liver disease and the increased mortality rate.
Furthermore, PWR may be an inexpensive, easily accessible, and significant independent prognostic index for mortality on multivariate analysis (HR = 0.660, 95% CI: 0.438–0.996, p=0.048) as well as model for end-stage liver disease (MELD) score.
Conclusions.
The PWR values were markedly decreased in ACLF patients compared with healthy controls and associated with severe liver disease.
Moreover, PWR was an independent prognostic indicator for the mortality rate in patients with ACLF.
This investigation highlights that PWR comprised a useful biomarker for prediction of liver severity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jie, Yusheng& Gong, Jiao& Xiao, Cuicui& Zhu, Shuguang& Zhou, Wenying& Luo, Juan…[et al.]. 2018. Low Platelet to White Blood Cell Ratio Indicates Poor Prognosis for Acute-On-Chronic Liver Failure. BioMed Research International،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1128475
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jie, Yusheng…[et al.]. Low Platelet to White Blood Cell Ratio Indicates Poor Prognosis for Acute-On-Chronic Liver Failure. BioMed Research International No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1128475
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jie, Yusheng& Gong, Jiao& Xiao, Cuicui& Zhu, Shuguang& Zhou, Wenying& Luo, Juan…[et al.]. Low Platelet to White Blood Cell Ratio Indicates Poor Prognosis for Acute-On-Chronic Liver Failure. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1128475
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1128475
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر