Low Platelet to White Blood Cell Ratio Indicates Poor Prognosis for Acute-On-Chronic Liver Failure
Joint Authors
Jie, Yusheng
Chong, Yutian
Gong, Jiao
Xiao, Cuicui
Zhu, Shuguang
Zhou, Wenying
Luo, Juan
Hu, Bo
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-08
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Platelet to white blood cell ratio (PWR) was an independent prognostic predictor for outcomes in some diseases.
However, the prognostic role of PWR is still unclear in patients with hepatitis B related acute-on-chronic liver failure (ACLF).
In this study, we evaluated the clinical performances of PWR in predicting prognosis in HBV-related ACLF.
Methods.
A total of 530 subjects were recruited, including 97 healthy controls and 433 with HBV-related ACLF.
Liver function, prothrombin time activity (PTA), international normalized ratio (INR), HBV DNA measurement, and routine hematological testing were performed at admission.
Results.
At baseline, PWR in patients with HBV-related ACLF (14.03 ± 7.17) was significantly decreased compared to those in healthy controls (39.16 ± 9.80).
Reduced PWR values were clinically associated with the severity of liver disease and the increased mortality rate.
Furthermore, PWR may be an inexpensive, easily accessible, and significant independent prognostic index for mortality on multivariate analysis (HR = 0.660, 95% CI: 0.438–0.996, p=0.048) as well as model for end-stage liver disease (MELD) score.
Conclusions.
The PWR values were markedly decreased in ACLF patients compared with healthy controls and associated with severe liver disease.
Moreover, PWR was an independent prognostic indicator for the mortality rate in patients with ACLF.
This investigation highlights that PWR comprised a useful biomarker for prediction of liver severity.
American Psychological Association (APA)
Jie, Yusheng& Gong, Jiao& Xiao, Cuicui& Zhu, Shuguang& Zhou, Wenying& Luo, Juan…[et al.]. 2018. Low Platelet to White Blood Cell Ratio Indicates Poor Prognosis for Acute-On-Chronic Liver Failure. BioMed Research International،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1128475
Modern Language Association (MLA)
Jie, Yusheng…[et al.]. Low Platelet to White Blood Cell Ratio Indicates Poor Prognosis for Acute-On-Chronic Liver Failure. BioMed Research International No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1128475
American Medical Association (AMA)
Jie, Yusheng& Gong, Jiao& Xiao, Cuicui& Zhu, Shuguang& Zhou, Wenying& Luo, Juan…[et al.]. Low Platelet to White Blood Cell Ratio Indicates Poor Prognosis for Acute-On-Chronic Liver Failure. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1128475
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128475