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Morphological Predictive Features on Spectral-Domain Optical Coherence Tomography for Visual Outcomes in Neovascular Age-Related Macular Degeneration Treated with Ranibizumab
المؤلفون المشاركون
Wolff, Benjamin
Azar, Georges
Sahyoun, Marwan
Halfon, Jeremie
Streho, Mate
Tick, Sarah
Castelnovo, Laurent
Michel, Guillaume
Masse, Helene
Vasseur, Vivien
Mauget-Faÿsse, Martine
De Bats, Flore
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-06-26
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Purpose.
To identify spectral-domain optical coherence tomography (SD-OCT) predictive morphological features for the outcome of Ranibizumab therapy for neovascular age-related macular degeneration (AMD).
Methods.
This is a retrospective multicentric study that involved 64 eyes with naïve AMD.
Patients who received three monthly intravitreal injections of Ranibizumab were stratified into (1) “responders” [≥ 5 letters gain on Early Treatment Diabetic Retinopathy Study (ETDRS) scale] and (2) “nonresponders” (< 5 letters gain).
Best-corrected visual acuity (BCVA) and SD-OCT morphological features were compared at baseline and one month after three consecutive injections of Ranibizumab.
Univariate and multivariate analyses were carried out to correlate these morphological features with the change in BCVA.
Results.
Among the 64 patients enrolled, 40 (62.5%) were “responders” and 24 (37.5%) “nonresponders”.
Age, sex, and BCVA were comparable between both groups.
A multivariate correlational analysis found that subfoveal choroidal thickness (SFCT) and the presence of pigment epithelial detachment (PED) > 250 μm at baseline were two independent prognostic indicators of final BCVA.
No other SD-OCT morphological studied features seem to affect final BCVA after Ranibizumab treatment.
Conclusion.
SFCT and the presence of PED > 250 μm are two significant biomarkers that may predict improvement after Ranibizumab therapy for AMD.
These markers may guide ophthalmologists' treatment decision under financial constraints and limited time.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Azar, Georges& Wolff, Benjamin& De Bats, Flore& Halfon, Jeremie& Streho, Mate& Tick, Sarah…[et al.]. 2018. Morphological Predictive Features on Spectral-Domain Optical Coherence Tomography for Visual Outcomes in Neovascular Age-Related Macular Degeneration Treated with Ranibizumab. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1128502
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Azar, Georges…[et al.]. Morphological Predictive Features on Spectral-Domain Optical Coherence Tomography for Visual Outcomes in Neovascular Age-Related Macular Degeneration Treated with Ranibizumab. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1128502
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Azar, Georges& Wolff, Benjamin& De Bats, Flore& Halfon, Jeremie& Streho, Mate& Tick, Sarah…[et al.]. Morphological Predictive Features on Spectral-Domain Optical Coherence Tomography for Visual Outcomes in Neovascular Age-Related Macular Degeneration Treated with Ranibizumab. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1128502
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1128502
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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