![](/images/graphics-bg.png)
Morphological Predictive Features on Spectral-Domain Optical Coherence Tomography for Visual Outcomes in Neovascular Age-Related Macular Degeneration Treated with Ranibizumab
Joint Authors
Wolff, Benjamin
Azar, Georges
Sahyoun, Marwan
Halfon, Jeremie
Streho, Mate
Tick, Sarah
Castelnovo, Laurent
Michel, Guillaume
Masse, Helene
Vasseur, Vivien
Mauget-Faÿsse, Martine
De Bats, Flore
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Purpose.
To identify spectral-domain optical coherence tomography (SD-OCT) predictive morphological features for the outcome of Ranibizumab therapy for neovascular age-related macular degeneration (AMD).
Methods.
This is a retrospective multicentric study that involved 64 eyes with naïve AMD.
Patients who received three monthly intravitreal injections of Ranibizumab were stratified into (1) “responders” [≥ 5 letters gain on Early Treatment Diabetic Retinopathy Study (ETDRS) scale] and (2) “nonresponders” (< 5 letters gain).
Best-corrected visual acuity (BCVA) and SD-OCT morphological features were compared at baseline and one month after three consecutive injections of Ranibizumab.
Univariate and multivariate analyses were carried out to correlate these morphological features with the change in BCVA.
Results.
Among the 64 patients enrolled, 40 (62.5%) were “responders” and 24 (37.5%) “nonresponders”.
Age, sex, and BCVA were comparable between both groups.
A multivariate correlational analysis found that subfoveal choroidal thickness (SFCT) and the presence of pigment epithelial detachment (PED) > 250 μm at baseline were two independent prognostic indicators of final BCVA.
No other SD-OCT morphological studied features seem to affect final BCVA after Ranibizumab treatment.
Conclusion.
SFCT and the presence of PED > 250 μm are two significant biomarkers that may predict improvement after Ranibizumab therapy for AMD.
These markers may guide ophthalmologists' treatment decision under financial constraints and limited time.
American Psychological Association (APA)
Azar, Georges& Wolff, Benjamin& De Bats, Flore& Halfon, Jeremie& Streho, Mate& Tick, Sarah…[et al.]. 2018. Morphological Predictive Features on Spectral-Domain Optical Coherence Tomography for Visual Outcomes in Neovascular Age-Related Macular Degeneration Treated with Ranibizumab. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1128502
Modern Language Association (MLA)
Azar, Georges…[et al.]. Morphological Predictive Features on Spectral-Domain Optical Coherence Tomography for Visual Outcomes in Neovascular Age-Related Macular Degeneration Treated with Ranibizumab. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1128502
American Medical Association (AMA)
Azar, Georges& Wolff, Benjamin& De Bats, Flore& Halfon, Jeremie& Streho, Mate& Tick, Sarah…[et al.]. Morphological Predictive Features on Spectral-Domain Optical Coherence Tomography for Visual Outcomes in Neovascular Age-Related Macular Degeneration Treated with Ranibizumab. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1128502
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128502