UCHL1PGP 9.5 Dynamic in Neuro-Immune-Cutaneous Milieu: Focusing on Axonal Nerve Terminals and Epidermal Keratinocytes in Psoriatic Itch
المؤلفون المشاركون
Ziółkowski, Piotr
Gajda, Mariusz
Jagodziński, Paweł P.
Szepietowski, J. C.
Reich, Adam
Kupczyk, Piotr
Hołysz, Marcin
Wysokińska, Edyta
Paprocka, Maria
Nevozhay, Dmitry
Chodaczek, Grzegorz
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-25
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Psoriasis is an immunogenetic skin disease manifesting as plaque lesions on the skin.
Patients with psoriasis frequently suffer from itch, an unpleasant sensation causing a desire to scratch.
Psoriatic itch is mainly transmitted by unmyelinated C-fibers; however, the exact molecular mechanism of psoriatic itch is still unexplained.
Protein gene product 9.5 (PGP 9.5) is a panneurological marker commonly used for analysis of peripheral peptidergic and nonpeptidergic nerves and identification of cutaneous neuro-immune-endocrine cells.
However, some studies suggested that nonneuronal cells, like keratinocytes, may also express PGP 9.5.
This phenomenon might be linked with impaired axonal transport, keratinocyte injury, or dysfunctions of neuro-immune-cutaneous connections.
The aim of this study was to analyze the expression of PGP 9.5 in psoriatic skin.
We observed significantly altered density of PGP 9.5-positive axonal nerve terminals in pruritic lesional (p=0.04) and nonlesional psoriatic skin (p>0.001) compared with controls.
In contrast, no significant differences were observed between psoriatic skin without itch and controls.
Furthermore, PGP 9.5 expression by suprabasal keratinocytes (SBKs) was significantly increased in itchy skin lesions (p=0.007) compared to skin without itch, and a positive correlation was observed between PGP 9.5 expression and itch intensity (r=0.64; p=0.02).
Our findings indicate changes in peripheral innervations and psoriatic keratinocytes, which may influence neuro-immune-cutaneous homeostasis and modulate itch transmission.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kupczyk, Piotr& Reich, Adam& Gajda, Mariusz& Hołysz, Marcin& Wysokińska, Edyta& Paprocka, Maria…[et al.]. 2018. UCHL1PGP 9.5 Dynamic in Neuro-Immune-Cutaneous Milieu: Focusing on Axonal Nerve Terminals and Epidermal Keratinocytes in Psoriatic Itch. BioMed Research International،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1128550
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kupczyk, Piotr…[et al.]. UCHL1PGP 9.5 Dynamic in Neuro-Immune-Cutaneous Milieu: Focusing on Axonal Nerve Terminals and Epidermal Keratinocytes in Psoriatic Itch. BioMed Research International No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1128550
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kupczyk, Piotr& Reich, Adam& Gajda, Mariusz& Hołysz, Marcin& Wysokińska, Edyta& Paprocka, Maria…[et al.]. UCHL1PGP 9.5 Dynamic in Neuro-Immune-Cutaneous Milieu: Focusing on Axonal Nerve Terminals and Epidermal Keratinocytes in Psoriatic Itch. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1128550
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1128550
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر