UCHL1PGP 9.5 Dynamic in Neuro-Immune-Cutaneous Milieu: Focusing on Axonal Nerve Terminals and Epidermal Keratinocytes in Psoriatic Itch
Joint Authors
Ziółkowski, Piotr
Gajda, Mariusz
Jagodziński, Paweł P.
Szepietowski, J. C.
Reich, Adam
Kupczyk, Piotr
Hołysz, Marcin
Wysokińska, Edyta
Paprocka, Maria
Nevozhay, Dmitry
Chodaczek, Grzegorz
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-25
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Psoriasis is an immunogenetic skin disease manifesting as plaque lesions on the skin.
Patients with psoriasis frequently suffer from itch, an unpleasant sensation causing a desire to scratch.
Psoriatic itch is mainly transmitted by unmyelinated C-fibers; however, the exact molecular mechanism of psoriatic itch is still unexplained.
Protein gene product 9.5 (PGP 9.5) is a panneurological marker commonly used for analysis of peripheral peptidergic and nonpeptidergic nerves and identification of cutaneous neuro-immune-endocrine cells.
However, some studies suggested that nonneuronal cells, like keratinocytes, may also express PGP 9.5.
This phenomenon might be linked with impaired axonal transport, keratinocyte injury, or dysfunctions of neuro-immune-cutaneous connections.
The aim of this study was to analyze the expression of PGP 9.5 in psoriatic skin.
We observed significantly altered density of PGP 9.5-positive axonal nerve terminals in pruritic lesional (p=0.04) and nonlesional psoriatic skin (p>0.001) compared with controls.
In contrast, no significant differences were observed between psoriatic skin without itch and controls.
Furthermore, PGP 9.5 expression by suprabasal keratinocytes (SBKs) was significantly increased in itchy skin lesions (p=0.007) compared to skin without itch, and a positive correlation was observed between PGP 9.5 expression and itch intensity (r=0.64; p=0.02).
Our findings indicate changes in peripheral innervations and psoriatic keratinocytes, which may influence neuro-immune-cutaneous homeostasis and modulate itch transmission.
American Psychological Association (APA)
Kupczyk, Piotr& Reich, Adam& Gajda, Mariusz& Hołysz, Marcin& Wysokińska, Edyta& Paprocka, Maria…[et al.]. 2018. UCHL1PGP 9.5 Dynamic in Neuro-Immune-Cutaneous Milieu: Focusing on Axonal Nerve Terminals and Epidermal Keratinocytes in Psoriatic Itch. BioMed Research International،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1128550
Modern Language Association (MLA)
Kupczyk, Piotr…[et al.]. UCHL1PGP 9.5 Dynamic in Neuro-Immune-Cutaneous Milieu: Focusing on Axonal Nerve Terminals and Epidermal Keratinocytes in Psoriatic Itch. BioMed Research International No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1128550
American Medical Association (AMA)
Kupczyk, Piotr& Reich, Adam& Gajda, Mariusz& Hołysz, Marcin& Wysokińska, Edyta& Paprocka, Maria…[et al.]. UCHL1PGP 9.5 Dynamic in Neuro-Immune-Cutaneous Milieu: Focusing on Axonal Nerve Terminals and Epidermal Keratinocytes in Psoriatic Itch. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1128550
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128550