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Development of a Novel Diagnostic Biomarker Set for Rheumatoid Arthritis Using a Proteomics Approach
المؤلفون المشاركون
Kang, Hee Kyu
Mun, Sora
Lee, Jiyeong
Lim, Mi-Kyoung
Lee, You-Rim
Ihm, Chunhwa
Lee, Seung Hoon
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-11-26
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Background.
Rheumatoid arthritis (RA) is an autoimmune disease that starts with inflammation of the synovial membrane.
Studies have been conducted to develop methods for efficient diagnosis of RA and to identify the mechanisms underlying RA development.
Blood samples can be useful for detecting disturbance of homeostasis in patients with RA.
Nanoliquid chromatography-tandem mass spectrometry (LC-MS/MS) is an efficient proteomics approach to analyze blood sample and quantify serum proteins.
Methods.
Serum samples of 18 healthy controls and 18 patients with RA were analyzed by LC-MS/MS.
Selected candidate biomarkers were validated by enzyme-linked immunosorbent assay (ELISA) using sera from 43 healthy controls and 44 patients with RA.
Results.
Thirty-eight proteins were significantly differentially expressed by more than 2-fold in healthy controls and patients with RA.
Based on a literature survey, we selected six candidate RA biomarkers.
ELISA was used to evaluate whether these proteins effectively allow distinguishing patients with RA from healthy controls and monitoring drug efficacy.
SAA4, gelsolin, and vitamin D-binding protein were validated as potential biomarkers of RA for screening and drug efficacy monitoring of RA.
Conclusions.
We identified a panel of three biomarkers for RA which has potential for application in RA diagnosis and drug efficacy monitoring.
Further, our findings will aid in understanding the pathogenesis of RA.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mun, Sora& Lee, Jiyeong& Lim, Mi-Kyoung& Lee, You-Rim& Ihm, Chunhwa& Lee, Seung Hoon…[et al.]. 2018. Development of a Novel Diagnostic Biomarker Set for Rheumatoid Arthritis Using a Proteomics Approach. BioMed Research International،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1128557
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mun, Sora…[et al.]. Development of a Novel Diagnostic Biomarker Set for Rheumatoid Arthritis Using a Proteomics Approach. BioMed Research International No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1128557
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mun, Sora& Lee, Jiyeong& Lim, Mi-Kyoung& Lee, You-Rim& Ihm, Chunhwa& Lee, Seung Hoon…[et al.]. Development of a Novel Diagnostic Biomarker Set for Rheumatoid Arthritis Using a Proteomics Approach. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1128557
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1128557
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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