Detection of Epithelial-Mesenchymal Transition Status of Circulating Tumor Cells in Patients with Esophageal Squamous Carcinoma
المؤلفون المشاركون
Li, Hecheng
Han, Dingpei
Chen, Kai
Che, Jiaming
Hang, Junbiao
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-06-26
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Purpose.
To investigate the correlation between the status of epithelial-mesenchymal transition (EMT) of circulating tumor cells (CTCs) and esophageal squamous cell carcinoma (ESCC).
Methods.
The demographic data and blood samples of 21 patients with ESCC were collected retrospectively.
CTCs were enriched by using optimized CanPatrolTM CTC enrichment technique.
CTCs were identified and characterized according to the EMT markers (e-CTCs: epithelial CTCs; mix-CTCs: epithelial-mesenchymal-mixed CTCs; m-CTCs: mesenchymal CTCs).
The correlation between CTCs and demographic data was analyzed.
Results.
Total 129 CTCs were detected in all the patients: 11(8.5%) CTCs of them were e-CTCs, 76(58.9%) were mix-CTCs, and 42(32.6%) were m-CTCs.
The average number of CTCs from each patient was 6.1±7.1 which included 0.5±0.9 of e-CTCs, 3.6±5.2 of mix-CTCs, and 2.0±2.7 of m-CTCs; the difference between the three groups was significant (P=0.017): the number of total CTCs was correlated with the number of mix-CTCs (R2=0.883, P<0.01) and m-CTCs (R2=0.639, P<0.01) but not e-CTCs (R2=0.012, P=0.641) and the number of CTCs was correlated with the N stage and TNM stage in this study (R2=0.698 and R2=0.359).
Conclusions.
Mix-CTCs and m-CTCs might play an important role in progression of ESCC; the number of CTCs in ESCC might have the potential to be a predictor of prognosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Han, Dingpei& Chen, Kai& Che, Jiaming& Hang, Junbiao& Li, Hecheng. 2018. Detection of Epithelial-Mesenchymal Transition Status of Circulating Tumor Cells in Patients with Esophageal Squamous Carcinoma. BioMed Research International،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1128628
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Han, Dingpei…[et al.]. Detection of Epithelial-Mesenchymal Transition Status of Circulating Tumor Cells in Patients with Esophageal Squamous Carcinoma. BioMed Research International No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1128628
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Han, Dingpei& Chen, Kai& Che, Jiaming& Hang, Junbiao& Li, Hecheng. Detection of Epithelial-Mesenchymal Transition Status of Circulating Tumor Cells in Patients with Esophageal Squamous Carcinoma. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1128628
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1128628
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر