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Detection of Epithelial-Mesenchymal Transition Status of Circulating Tumor Cells in Patients with Esophageal Squamous Carcinoma
Joint Authors
Li, Hecheng
Han, Dingpei
Chen, Kai
Che, Jiaming
Hang, Junbiao
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-26
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Purpose.
To investigate the correlation between the status of epithelial-mesenchymal transition (EMT) of circulating tumor cells (CTCs) and esophageal squamous cell carcinoma (ESCC).
Methods.
The demographic data and blood samples of 21 patients with ESCC were collected retrospectively.
CTCs were enriched by using optimized CanPatrolTM CTC enrichment technique.
CTCs were identified and characterized according to the EMT markers (e-CTCs: epithelial CTCs; mix-CTCs: epithelial-mesenchymal-mixed CTCs; m-CTCs: mesenchymal CTCs).
The correlation between CTCs and demographic data was analyzed.
Results.
Total 129 CTCs were detected in all the patients: 11(8.5%) CTCs of them were e-CTCs, 76(58.9%) were mix-CTCs, and 42(32.6%) were m-CTCs.
The average number of CTCs from each patient was 6.1±7.1 which included 0.5±0.9 of e-CTCs, 3.6±5.2 of mix-CTCs, and 2.0±2.7 of m-CTCs; the difference between the three groups was significant (P=0.017): the number of total CTCs was correlated with the number of mix-CTCs (R2=0.883, P<0.01) and m-CTCs (R2=0.639, P<0.01) but not e-CTCs (R2=0.012, P=0.641) and the number of CTCs was correlated with the N stage and TNM stage in this study (R2=0.698 and R2=0.359).
Conclusions.
Mix-CTCs and m-CTCs might play an important role in progression of ESCC; the number of CTCs in ESCC might have the potential to be a predictor of prognosis.
American Psychological Association (APA)
Han, Dingpei& Chen, Kai& Che, Jiaming& Hang, Junbiao& Li, Hecheng. 2018. Detection of Epithelial-Mesenchymal Transition Status of Circulating Tumor Cells in Patients with Esophageal Squamous Carcinoma. BioMed Research International،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1128628
Modern Language Association (MLA)
Han, Dingpei…[et al.]. Detection of Epithelial-Mesenchymal Transition Status of Circulating Tumor Cells in Patients with Esophageal Squamous Carcinoma. BioMed Research International No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1128628
American Medical Association (AMA)
Han, Dingpei& Chen, Kai& Che, Jiaming& Hang, Junbiao& Li, Hecheng. Detection of Epithelial-Mesenchymal Transition Status of Circulating Tumor Cells in Patients with Esophageal Squamous Carcinoma. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1128628
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128628