Effect of Long-Term Sodium Salicylate Administration on Learning, Memory, and Neurogenesis in the Rat Hippocampus
المؤلفون المشاركون
Huma, Tanzeel
Niu, Haichen
Ding, Sheng
Li, Haiying
Wei, Jianfeng
Ren, Chao
Wu, Xiujuan
Zhang, Qiang
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-01
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Tinnitus is thought to be caused by damage to the auditory and nonauditory system due to exposure to loud noise, aging, or other etiologies.
However, at present, the exact neurophysiological basis of chronic tinnitus remains unknown.
To explore whether the function of the limbic system is disturbed in tinnitus, the hippocampus was selected, which plays a vital role in learning and memory.
The hippocampal function was examined with a learning and memory procedure.
For this purpose, sodium salicylate (NaSal) was used to create a rat animal model of tinnitus, evaluated with prepulse inhibition behavior (PPI).
The acquisition and retrieval abilities of spatial memory were measured using the Morris water maze (MWM) in NaSal-treated and control animals, followed by observation of c-Fos and delta-FosB protein expression in the hippocampal field by immunohistochemistry.
To further identify the neural substrate for memory change in tinnitus, neurogenesis in the subgranular zone of the dentate gyrus (DG) was compared between the NaSal group and the control group.
The results showed that acquisition and retrieval of spatial memory were impaired by NaSal treatment.
The expression of c-Fos and delta-FosB protein was also inhibited in NaSal-treated animals.
Simultaneously, neurogenesis in the DG was also impaired in tinnitus animals.
In general, our data suggest that the hippocampal system (limbic system) may play a key role in tinnitus pathology.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Niu, Haichen& Ding, Sheng& Li, Haiying& Wei, Jianfeng& Ren, Chao& Wu, Xiujuan…[et al.]. 2018. Effect of Long-Term Sodium Salicylate Administration on Learning, Memory, and Neurogenesis in the Rat Hippocampus. BioMed Research International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1128705
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Niu, Haichen…[et al.]. Effect of Long-Term Sodium Salicylate Administration on Learning, Memory, and Neurogenesis in the Rat Hippocampus. BioMed Research International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1128705
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Niu, Haichen& Ding, Sheng& Li, Haiying& Wei, Jianfeng& Ren, Chao& Wu, Xiujuan…[et al.]. Effect of Long-Term Sodium Salicylate Administration on Learning, Memory, and Neurogenesis in the Rat Hippocampus. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1128705
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1128705
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر