Effect of Long-Term Sodium Salicylate Administration on Learning, Memory, and Neurogenesis in the Rat Hippocampus
Joint Authors
Huma, Tanzeel
Niu, Haichen
Ding, Sheng
Li, Haiying
Wei, Jianfeng
Ren, Chao
Wu, Xiujuan
Zhang, Qiang
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-01
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Tinnitus is thought to be caused by damage to the auditory and nonauditory system due to exposure to loud noise, aging, or other etiologies.
However, at present, the exact neurophysiological basis of chronic tinnitus remains unknown.
To explore whether the function of the limbic system is disturbed in tinnitus, the hippocampus was selected, which plays a vital role in learning and memory.
The hippocampal function was examined with a learning and memory procedure.
For this purpose, sodium salicylate (NaSal) was used to create a rat animal model of tinnitus, evaluated with prepulse inhibition behavior (PPI).
The acquisition and retrieval abilities of spatial memory were measured using the Morris water maze (MWM) in NaSal-treated and control animals, followed by observation of c-Fos and delta-FosB protein expression in the hippocampal field by immunohistochemistry.
To further identify the neural substrate for memory change in tinnitus, neurogenesis in the subgranular zone of the dentate gyrus (DG) was compared between the NaSal group and the control group.
The results showed that acquisition and retrieval of spatial memory were impaired by NaSal treatment.
The expression of c-Fos and delta-FosB protein was also inhibited in NaSal-treated animals.
Simultaneously, neurogenesis in the DG was also impaired in tinnitus animals.
In general, our data suggest that the hippocampal system (limbic system) may play a key role in tinnitus pathology.
American Psychological Association (APA)
Niu, Haichen& Ding, Sheng& Li, Haiying& Wei, Jianfeng& Ren, Chao& Wu, Xiujuan…[et al.]. 2018. Effect of Long-Term Sodium Salicylate Administration on Learning, Memory, and Neurogenesis in the Rat Hippocampus. BioMed Research International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1128705
Modern Language Association (MLA)
Niu, Haichen…[et al.]. Effect of Long-Term Sodium Salicylate Administration on Learning, Memory, and Neurogenesis in the Rat Hippocampus. BioMed Research International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1128705
American Medical Association (AMA)
Niu, Haichen& Ding, Sheng& Li, Haiying& Wei, Jianfeng& Ren, Chao& Wu, Xiujuan…[et al.]. Effect of Long-Term Sodium Salicylate Administration on Learning, Memory, and Neurogenesis in the Rat Hippocampus. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1128705
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128705