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Anthropogenetic Variability in the Group of Individuals with Febrile Seizures: Population-Genetic Study
المؤلفون المشاركون
Dimitrijevic, Sanja
Cvjeticanin, Suzana
Pusica, Aleksandra
Jekic, Biljana
Filipovic, Tamara
Nikolic, Dimitrije
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-05
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Febrile seizures (FS) are the most common neurological disorder in childhood and are a great stress for parents due to their dramatic clinical appearance.
Using test for determination of homozygously recessive characteristics in humans (HRC test) we analyzed presence, distribution, and individual combination of 20 selected genetically controlled morphophysiological traits among FS patients (N=121) and control (N=121) to determine a possible deviation in the homozygosity level and genetic loads in the group of affected children and whether there is a predisposition to the occurrence of FS.
The results of our study show a statistically significant difference in the mean values of the HRC tested (x¯HRC/20 CN = 3.2 ± 0.2; x¯HRC/20 FS = 4.6 ± 0.2, t= 5.74 , p< 0.0001), as well as in the distribution and variability of two studied samples (VC=55,3%, VFS= 39,6%), which indicates a complex polygenic difference among the tested groups of subjects.
The differences in the degree of genetic homozygosity and variability are also present between the genders (t Cf/FSf = 4.12; t Cm/FSm = 3.98; p <0.0001) (VCf=56.9%, VFSf= 39.3%; VCm=54.1%, VFSm=40.1%).
Obtained results indicate the enlargement of recessively homozygous genetic loads in the group of children with FS which may represent some kind of predisposition for expressivity of this type of seizures.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dimitrijevic, Sanja& Cvjeticanin, Suzana& Pusica, Aleksandra& Jekic, Biljana& Filipovic, Tamara& Nikolic, Dimitrije. 2018. Anthropogenetic Variability in the Group of Individuals with Febrile Seizures: Population-Genetic Study. BioMed Research International،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1128735
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dimitrijevic, Sanja…[et al.]. Anthropogenetic Variability in the Group of Individuals with Febrile Seizures: Population-Genetic Study. BioMed Research International No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1128735
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dimitrijevic, Sanja& Cvjeticanin, Suzana& Pusica, Aleksandra& Jekic, Biljana& Filipovic, Tamara& Nikolic, Dimitrije. Anthropogenetic Variability in the Group of Individuals with Febrile Seizures: Population-Genetic Study. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1128735
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1128735
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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