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Anthropogenetic Variability in the Group of Individuals with Febrile Seizures: Population-Genetic Study
Joint Authors
Dimitrijevic, Sanja
Cvjeticanin, Suzana
Pusica, Aleksandra
Jekic, Biljana
Filipovic, Tamara
Nikolic, Dimitrije
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-05
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Febrile seizures (FS) are the most common neurological disorder in childhood and are a great stress for parents due to their dramatic clinical appearance.
Using test for determination of homozygously recessive characteristics in humans (HRC test) we analyzed presence, distribution, and individual combination of 20 selected genetically controlled morphophysiological traits among FS patients (N=121) and control (N=121) to determine a possible deviation in the homozygosity level and genetic loads in the group of affected children and whether there is a predisposition to the occurrence of FS.
The results of our study show a statistically significant difference in the mean values of the HRC tested (x¯HRC/20 CN = 3.2 ± 0.2; x¯HRC/20 FS = 4.6 ± 0.2, t= 5.74 , p< 0.0001), as well as in the distribution and variability of two studied samples (VC=55,3%, VFS= 39,6%), which indicates a complex polygenic difference among the tested groups of subjects.
The differences in the degree of genetic homozygosity and variability are also present between the genders (t Cf/FSf = 4.12; t Cm/FSm = 3.98; p <0.0001) (VCf=56.9%, VFSf= 39.3%; VCm=54.1%, VFSm=40.1%).
Obtained results indicate the enlargement of recessively homozygous genetic loads in the group of children with FS which may represent some kind of predisposition for expressivity of this type of seizures.
American Psychological Association (APA)
Dimitrijevic, Sanja& Cvjeticanin, Suzana& Pusica, Aleksandra& Jekic, Biljana& Filipovic, Tamara& Nikolic, Dimitrije. 2018. Anthropogenetic Variability in the Group of Individuals with Febrile Seizures: Population-Genetic Study. BioMed Research International،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1128735
Modern Language Association (MLA)
Dimitrijevic, Sanja…[et al.]. Anthropogenetic Variability in the Group of Individuals with Febrile Seizures: Population-Genetic Study. BioMed Research International No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1128735
American Medical Association (AMA)
Dimitrijevic, Sanja& Cvjeticanin, Suzana& Pusica, Aleksandra& Jekic, Biljana& Filipovic, Tamara& Nikolic, Dimitrije. Anthropogenetic Variability in the Group of Individuals with Febrile Seizures: Population-Genetic Study. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1128735
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128735