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Osteonecrosis of the Jaw Associated with Antiangiogenics in Antiresorptive-Naïve Patient: A Comprehensive Review of the Literature
المؤلفون المشاركون
Pimolbutr, Kununya
Porter, Stephen
Fedele, Stefano
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-23
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Objectives.
To review the available literature on medication-related osteonecrosis of the jaw (MRONJ) associated with antiangiogenics in antiresorptive-naïve individuals.
Methods.
A literature search was performed using MEDLINE via PubMed, EMBASE, and Web of Science in December 2017.
Results.
We identified reports describing a total of 35 antiresorptive drugs-naïve patients who developed antiangiogenic-related MRONJ.
The mean age of these patients was 59.06 years and the F : M ratio was 4 : 5.
The most common underlying disease was metastatic renal cell cancer.
Pain to the mandible was the most common complaint (34.29%) and the majority of patients presented with bone exposure.
The mean duration of intravenous and oral antiangiogenics before MRONJ development was 6.5 and 16.72 months, respectively.
The most common additional risk factor was dental extraction (37.14%).
Almost half of the MRONJ patients (48.57%) received surgical treatment.
18 patients (62.06%) were reported to have disease resolution within an average time of 6.75 months.
Conclusion.
MRONJ associated with antiangiogenic therapy in antiresorptive-naïve patients is a rare but potentially serious adverse effect.
Available data suggests that there might be notable differences between MRONJ associated with antiangiogenics and antiresorptives; however, further prospective well-designed studies are required.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pimolbutr, Kununya& Porter, Stephen& Fedele, Stefano. 2018. Osteonecrosis of the Jaw Associated with Antiangiogenics in Antiresorptive-Naïve Patient: A Comprehensive Review of the Literature. BioMed Research International،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1128880
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pimolbutr, Kununya…[et al.]. Osteonecrosis of the Jaw Associated with Antiangiogenics in Antiresorptive-Naïve Patient: A Comprehensive Review of the Literature. BioMed Research International No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1128880
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pimolbutr, Kununya& Porter, Stephen& Fedele, Stefano. Osteonecrosis of the Jaw Associated with Antiangiogenics in Antiresorptive-Naïve Patient: A Comprehensive Review of the Literature. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1128880
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1128880
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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