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Osteonecrosis of the Jaw Associated with Antiangiogenics in Antiresorptive-Naïve Patient: A Comprehensive Review of the Literature
Joint Authors
Pimolbutr, Kununya
Porter, Stephen
Fedele, Stefano
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-23
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Objectives.
To review the available literature on medication-related osteonecrosis of the jaw (MRONJ) associated with antiangiogenics in antiresorptive-naïve individuals.
Methods.
A literature search was performed using MEDLINE via PubMed, EMBASE, and Web of Science in December 2017.
Results.
We identified reports describing a total of 35 antiresorptive drugs-naïve patients who developed antiangiogenic-related MRONJ.
The mean age of these patients was 59.06 years and the F : M ratio was 4 : 5.
The most common underlying disease was metastatic renal cell cancer.
Pain to the mandible was the most common complaint (34.29%) and the majority of patients presented with bone exposure.
The mean duration of intravenous and oral antiangiogenics before MRONJ development was 6.5 and 16.72 months, respectively.
The most common additional risk factor was dental extraction (37.14%).
Almost half of the MRONJ patients (48.57%) received surgical treatment.
18 patients (62.06%) were reported to have disease resolution within an average time of 6.75 months.
Conclusion.
MRONJ associated with antiangiogenic therapy in antiresorptive-naïve patients is a rare but potentially serious adverse effect.
Available data suggests that there might be notable differences between MRONJ associated with antiangiogenics and antiresorptives; however, further prospective well-designed studies are required.
American Psychological Association (APA)
Pimolbutr, Kununya& Porter, Stephen& Fedele, Stefano. 2018. Osteonecrosis of the Jaw Associated with Antiangiogenics in Antiresorptive-Naïve Patient: A Comprehensive Review of the Literature. BioMed Research International،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1128880
Modern Language Association (MLA)
Pimolbutr, Kununya…[et al.]. Osteonecrosis of the Jaw Associated with Antiangiogenics in Antiresorptive-Naïve Patient: A Comprehensive Review of the Literature. BioMed Research International No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1128880
American Medical Association (AMA)
Pimolbutr, Kununya& Porter, Stephen& Fedele, Stefano. Osteonecrosis of the Jaw Associated with Antiangiogenics in Antiresorptive-Naïve Patient: A Comprehensive Review of the Literature. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1128880
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128880