Alpha-L-Fucosidase Serves as a Prognostic Indicator for Intrahepatic Cholangiocarcinoma and Inhibits Its Invasion Capacity
المؤلفون المشاركون
Shuang, Zeyu
Mao, Yize
Lin, Guohe
Wang, Jun
Huang, Xin
Chen, Jianlin
Duan, Fangting
Li, Shengping
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-22
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Alpha-L-fucosidase (AFU) has been reported to be a predictor of survival in patients with several cancers, but it is unclear whether AFU is associated with prognosis in patients with intrahepatic cholangiocarcinoma (iCCA).
In this study, we used receiver operating characteristic (ROC) analysis to generate the cutoff point of AFU for overall survival (OS).
The prognostic influence of the AFU level in serum on OS was studied using Kaplan-Meier curves.
Moreover, invasion assays and Western blotting were performed to explore the effects of AFU on iCCA invasion in vitro.
We found that higher AFU levels (≥20.85 U/L) were significantly associated with favorable median OS (44.3 months versus 20.1 months; P=0.022) in iCCA patients.
Cox regression models’ analyses showed that the AFU level was an independent predictor for OS (P=0.006).
Moreover, our results revealed that the AFU could impair the invasion capability of the iCCA cells, HuH28, and also downregulated the expression of matrix metalloproteinase 2 and matrix metalloproteinase 9.
In conclusion, our results indicate that AFU is a significantly favorable prognostic factor in iCCA patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shuang, Zeyu& Mao, Yize& Lin, Guohe& Wang, Jun& Huang, Xin& Chen, Jianlin…[et al.]. 2018. Alpha-L-Fucosidase Serves as a Prognostic Indicator for Intrahepatic Cholangiocarcinoma and Inhibits Its Invasion Capacity. BioMed Research International،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1128949
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shuang, Zeyu…[et al.]. Alpha-L-Fucosidase Serves as a Prognostic Indicator for Intrahepatic Cholangiocarcinoma and Inhibits Its Invasion Capacity. BioMed Research International No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1128949
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shuang, Zeyu& Mao, Yize& Lin, Guohe& Wang, Jun& Huang, Xin& Chen, Jianlin…[et al.]. Alpha-L-Fucosidase Serves as a Prognostic Indicator for Intrahepatic Cholangiocarcinoma and Inhibits Its Invasion Capacity. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1128949
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1128949
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر