Alpha-L-Fucosidase Serves as a Prognostic Indicator for Intrahepatic Cholangiocarcinoma and Inhibits Its Invasion Capacity
Joint Authors
Shuang, Zeyu
Mao, Yize
Lin, Guohe
Wang, Jun
Huang, Xin
Chen, Jianlin
Duan, Fangting
Li, Shengping
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Alpha-L-fucosidase (AFU) has been reported to be a predictor of survival in patients with several cancers, but it is unclear whether AFU is associated with prognosis in patients with intrahepatic cholangiocarcinoma (iCCA).
In this study, we used receiver operating characteristic (ROC) analysis to generate the cutoff point of AFU for overall survival (OS).
The prognostic influence of the AFU level in serum on OS was studied using Kaplan-Meier curves.
Moreover, invasion assays and Western blotting were performed to explore the effects of AFU on iCCA invasion in vitro.
We found that higher AFU levels (≥20.85 U/L) were significantly associated with favorable median OS (44.3 months versus 20.1 months; P=0.022) in iCCA patients.
Cox regression models’ analyses showed that the AFU level was an independent predictor for OS (P=0.006).
Moreover, our results revealed that the AFU could impair the invasion capability of the iCCA cells, HuH28, and also downregulated the expression of matrix metalloproteinase 2 and matrix metalloproteinase 9.
In conclusion, our results indicate that AFU is a significantly favorable prognostic factor in iCCA patients.
American Psychological Association (APA)
Shuang, Zeyu& Mao, Yize& Lin, Guohe& Wang, Jun& Huang, Xin& Chen, Jianlin…[et al.]. 2018. Alpha-L-Fucosidase Serves as a Prognostic Indicator for Intrahepatic Cholangiocarcinoma and Inhibits Its Invasion Capacity. BioMed Research International،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1128949
Modern Language Association (MLA)
Shuang, Zeyu…[et al.]. Alpha-L-Fucosidase Serves as a Prognostic Indicator for Intrahepatic Cholangiocarcinoma and Inhibits Its Invasion Capacity. BioMed Research International No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1128949
American Medical Association (AMA)
Shuang, Zeyu& Mao, Yize& Lin, Guohe& Wang, Jun& Huang, Xin& Chen, Jianlin…[et al.]. Alpha-L-Fucosidase Serves as a Prognostic Indicator for Intrahepatic Cholangiocarcinoma and Inhibits Its Invasion Capacity. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1128949
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128949