Fecal Microbiota Transplantation Can Alleviate Gastrointestinal Transit in Rats with High-Fat Diet-Induced Obesity via Regulation of Serotonin Biosynthesis

المؤلفون المشاركون

Chen, Dongfeng
Sun, Wenjing
Guo, Yan
Zhang, Shirong
Chen, Zhihui
Wu, Kangqi
Liu, Qin
Wen, Liangzhi
Wei, Yanling
Wang, Bin
Liu, Kaijun

المصدر

BioMed Research International

العدد

المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2018-10-02

دولة النشر

مصر

عدد الصفحات

9

التخصصات الرئيسية

الطب البشري

الملخص EN

Aim.

We tested the hypothesis that fecal microbiota transplantation (FMT) could regulate the biotransformation of bile acids, such as deoxycholic acid (DCA) and cholic acid (CA), which in turn regulate the biosynthesis of serotonin in the gut and relieve gastrointestinal dysmotility in high-fat diet- (HFD-) induced obesity in rats.

Methods.

Male Sprague-Dawley rats were randomly divided into the control diet group, HFD group, and HFD-fed with receiving FMT.

HFD was fed for 12 weeks.

At the end of two-week HFD, FMT was carried out for two weeks.

The gastrointestinal transit, serotonin concentration, the expression of tryptophan hydroxylase 1 (TPH1) and serotonin reuptake transporter (SERT), and the levels of bile acids in intestinal contents were examined.

Results.

Compared with the control group, the gastrointestinal transit and small intestinal serotonin concentration of HFD-fed rats were increased.

In HFD-fed rats, TPH1 protein expression was increased significantly, while SERT protein expression was decreased, but not significant.

The levels of CA and DCA in intestinal contents were also significantly increased in HFD-fed rats compared with the control group.

After HFD-fed rats receiving FMT treatment, the gastrointestinal transit, small intestinal serotonin concentration, and TPH1 expression were decreased, while SERT expression was not affected.

Moreover, the levels of CA and DCA in intestinal contents were also decreased.

Conclusions.

FMT could alleviate small intestinal transit in the HFD-fed rats by regulating the serotonin biosynthesis.

In this process, CA and DCA may be related to the regulation of synthesis of serotonin.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Sun, Wenjing& Guo, Yan& Zhang, Shirong& Chen, Zhihui& Wu, Kangqi& Liu, Qin…[et al.]. 2018. Fecal Microbiota Transplantation Can Alleviate Gastrointestinal Transit in Rats with High-Fat Diet-Induced Obesity via Regulation of Serotonin Biosynthesis. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1129054

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Sun, Wenjing…[et al.]. Fecal Microbiota Transplantation Can Alleviate Gastrointestinal Transit in Rats with High-Fat Diet-Induced Obesity via Regulation of Serotonin Biosynthesis. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1129054

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Sun, Wenjing& Guo, Yan& Zhang, Shirong& Chen, Zhihui& Wu, Kangqi& Liu, Qin…[et al.]. Fecal Microbiota Transplantation Can Alleviate Gastrointestinal Transit in Rats with High-Fat Diet-Induced Obesity via Regulation of Serotonin Biosynthesis. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1129054

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1129054