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Fecal Microbiota Transplantation Can Alleviate Gastrointestinal Transit in Rats with High-Fat Diet-Induced Obesity via Regulation of Serotonin Biosynthesis
Joint Authors
Chen, Dongfeng
Sun, Wenjing
Guo, Yan
Zhang, Shirong
Chen, Zhihui
Wu, Kangqi
Liu, Qin
Wen, Liangzhi
Wei, Yanling
Wang, Bin
Liu, Kaijun
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Aim.
We tested the hypothesis that fecal microbiota transplantation (FMT) could regulate the biotransformation of bile acids, such as deoxycholic acid (DCA) and cholic acid (CA), which in turn regulate the biosynthesis of serotonin in the gut and relieve gastrointestinal dysmotility in high-fat diet- (HFD-) induced obesity in rats.
Methods.
Male Sprague-Dawley rats were randomly divided into the control diet group, HFD group, and HFD-fed with receiving FMT.
HFD was fed for 12 weeks.
At the end of two-week HFD, FMT was carried out for two weeks.
The gastrointestinal transit, serotonin concentration, the expression of tryptophan hydroxylase 1 (TPH1) and serotonin reuptake transporter (SERT), and the levels of bile acids in intestinal contents were examined.
Results.
Compared with the control group, the gastrointestinal transit and small intestinal serotonin concentration of HFD-fed rats were increased.
In HFD-fed rats, TPH1 protein expression was increased significantly, while SERT protein expression was decreased, but not significant.
The levels of CA and DCA in intestinal contents were also significantly increased in HFD-fed rats compared with the control group.
After HFD-fed rats receiving FMT treatment, the gastrointestinal transit, small intestinal serotonin concentration, and TPH1 expression were decreased, while SERT expression was not affected.
Moreover, the levels of CA and DCA in intestinal contents were also decreased.
Conclusions.
FMT could alleviate small intestinal transit in the HFD-fed rats by regulating the serotonin biosynthesis.
In this process, CA and DCA may be related to the regulation of synthesis of serotonin.
American Psychological Association (APA)
Sun, Wenjing& Guo, Yan& Zhang, Shirong& Chen, Zhihui& Wu, Kangqi& Liu, Qin…[et al.]. 2018. Fecal Microbiota Transplantation Can Alleviate Gastrointestinal Transit in Rats with High-Fat Diet-Induced Obesity via Regulation of Serotonin Biosynthesis. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1129054
Modern Language Association (MLA)
Sun, Wenjing…[et al.]. Fecal Microbiota Transplantation Can Alleviate Gastrointestinal Transit in Rats with High-Fat Diet-Induced Obesity via Regulation of Serotonin Biosynthesis. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1129054
American Medical Association (AMA)
Sun, Wenjing& Guo, Yan& Zhang, Shirong& Chen, Zhihui& Wu, Kangqi& Liu, Qin…[et al.]. Fecal Microbiota Transplantation Can Alleviate Gastrointestinal Transit in Rats with High-Fat Diet-Induced Obesity via Regulation of Serotonin Biosynthesis. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1129054
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129054