Meta-Analysis of miRNAs and Their Involvement as Biomarkers in Oral Cancers
المؤلفون المشاركون
Zahra, Andleeb
Rubab, Itrat
Malik, Sumaira
Khan, Amina
Khan, Muhammad Jawad
Fatmi, M. Qaiser
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-01-04
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Oral Squamous Cell Carcinoma (OSCC) is one of the most common cancers worldwide.
Recent studies have highlighted the role of miRNA in disease pathology, indicating its potential use as an early diagnostic marker.
Dysregulated expression of miRNAs is known to affect cell growth, and these may function as tumor suppressors or oncogenes in various cancers.
The main objective of this study was to characterize the extracellular miRNAs involved in oral cancer (OC) that can potentially be used as biomarkers of OC.
A total of 318 miRNAs involved in oral carcinoma were shortlisted.
Differentially expressed genes (DEGs) of oral carcinoma from reported experiments were identified.
Common genes between lists of DEGs of OC of each miRNA were identified.
These common genes are the targets of specific miRNA, which may be used as biomarkers of OC.
A list of significant biomarkers for cancer was generated like CDH2 and CDK7, and functional enrichment analysis identified the role of miRNAs in major pathways like cell adhesion molecules pathway affected by cancer.
We observed that at least 25 genes like ABCF3, ALDH2, CD163L1, and so forth are regulated by a maximum number of miRNAs; thereby, they can be used as biomarkers of OC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zahra, Andleeb& Rubab, Itrat& Malik, Sumaira& Khan, Amina& Khan, Muhammad Jawad& Fatmi, M. Qaiser. 2018. Meta-Analysis of miRNAs and Their Involvement as Biomarkers in Oral Cancers. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1129151
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zahra, Andleeb…[et al.]. Meta-Analysis of miRNAs and Their Involvement as Biomarkers in Oral Cancers. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1129151
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zahra, Andleeb& Rubab, Itrat& Malik, Sumaira& Khan, Amina& Khan, Muhammad Jawad& Fatmi, M. Qaiser. Meta-Analysis of miRNAs and Their Involvement as Biomarkers in Oral Cancers. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1129151
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1129151
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر