Meta-Analysis of miRNAs and Their Involvement as Biomarkers in Oral Cancers
Joint Authors
Zahra, Andleeb
Rubab, Itrat
Malik, Sumaira
Khan, Amina
Khan, Muhammad Jawad
Fatmi, M. Qaiser
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Oral Squamous Cell Carcinoma (OSCC) is one of the most common cancers worldwide.
Recent studies have highlighted the role of miRNA in disease pathology, indicating its potential use as an early diagnostic marker.
Dysregulated expression of miRNAs is known to affect cell growth, and these may function as tumor suppressors or oncogenes in various cancers.
The main objective of this study was to characterize the extracellular miRNAs involved in oral cancer (OC) that can potentially be used as biomarkers of OC.
A total of 318 miRNAs involved in oral carcinoma were shortlisted.
Differentially expressed genes (DEGs) of oral carcinoma from reported experiments were identified.
Common genes between lists of DEGs of OC of each miRNA were identified.
These common genes are the targets of specific miRNA, which may be used as biomarkers of OC.
A list of significant biomarkers for cancer was generated like CDH2 and CDK7, and functional enrichment analysis identified the role of miRNAs in major pathways like cell adhesion molecules pathway affected by cancer.
We observed that at least 25 genes like ABCF3, ALDH2, CD163L1, and so forth are regulated by a maximum number of miRNAs; thereby, they can be used as biomarkers of OC.
American Psychological Association (APA)
Zahra, Andleeb& Rubab, Itrat& Malik, Sumaira& Khan, Amina& Khan, Muhammad Jawad& Fatmi, M. Qaiser. 2018. Meta-Analysis of miRNAs and Their Involvement as Biomarkers in Oral Cancers. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1129151
Modern Language Association (MLA)
Zahra, Andleeb…[et al.]. Meta-Analysis of miRNAs and Their Involvement as Biomarkers in Oral Cancers. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1129151
American Medical Association (AMA)
Zahra, Andleeb& Rubab, Itrat& Malik, Sumaira& Khan, Amina& Khan, Muhammad Jawad& Fatmi, M. Qaiser. Meta-Analysis of miRNAs and Their Involvement as Biomarkers in Oral Cancers. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1129151
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129151