Positive Effects against UV-A Induced Damage and Oxidative Stress on an In Vitro Cell Model Using a Hyaluronic Acid Based Formulation Containing Amino Acids, Vitamins, and Minerals
المؤلفون المشاركون
Stellavato, Antonietta
Vassallo, Valentina
De Rosa, Mario
Schiraldi, Chiara
Pirozzi, Anna Virginia Adriana
Donato, Stella
Scognamiglio, Ilaria
Reale, Sabrina
Di Pardo, Alba
Filosa, Stefania
Bellia, Gilberto
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-06-26
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Ultraviolet (UV) radiations are responsible for skin photoaging inducing alteration of the molecular and cellular pathways resulting in dryness and reduction of skin elasticity.
In this study, we investigated, in vitro, the antiaging and antioxidant effects of hyaluronan formulations based hydrogel.
Skinkò E, an intradermic formulation composed of hyaluronic acid (HA), minerals, amino acids, and vitamins, was compared with the sole HA of the same size.
For this purpose, HaCaT cells were subjected to UV-A radiations and H2O2 exposure and then treated with growth medium (CTR) combined with M-HA or Skinkò E to evaluate their protective ability against stressful conditions.
Cells reparation was evaluated using a scratch in vitro model and Time-Lapse Video Microscopy.
A significant protective effect for Skinkò E was shown with respect to M-HA.
In addition, Skinkò E increased cell reparation.
Therefore, NF-kB, SOD-2, and HO-1 were significantly reduced at the transcriptional and protein level.
Interestingly, γ-H2AX and protein damage assay confirmed the protection by hyaluronans tested against oxidative stress.
G6pdΔ ES cell line, highly susceptible to oxidative stress, was used as a further cellular model to assess the antioxidant effect of Skinkò E.
Western blotting analyses showed that the treatment with this new formulation exerts marked antioxidant action in cells exposed to UV-A and H2O2.
Thus, the protective and reparative properties of Skinkò E make it an interesting tool to treat skin aging.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Stellavato, Antonietta& Pirozzi, Anna Virginia Adriana& Donato, Stella& Scognamiglio, Ilaria& Reale, Sabrina& Di Pardo, Alba…[et al.]. 2018. Positive Effects against UV-A Induced Damage and Oxidative Stress on an In Vitro Cell Model Using a Hyaluronic Acid Based Formulation Containing Amino Acids, Vitamins, and Minerals. BioMed Research International،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1129182
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Stellavato, Antonietta…[et al.]. Positive Effects against UV-A Induced Damage and Oxidative Stress on an In Vitro Cell Model Using a Hyaluronic Acid Based Formulation Containing Amino Acids, Vitamins, and Minerals. BioMed Research International No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1129182
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Stellavato, Antonietta& Pirozzi, Anna Virginia Adriana& Donato, Stella& Scognamiglio, Ilaria& Reale, Sabrina& Di Pardo, Alba…[et al.]. Positive Effects against UV-A Induced Damage and Oxidative Stress on an In Vitro Cell Model Using a Hyaluronic Acid Based Formulation Containing Amino Acids, Vitamins, and Minerals. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1129182
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1129182
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر