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Association between a Genetic Risk Score Based on Single Nucleotide Polymorphisms of Coronary Artery Disease-Related Genes and Left Main Coronary Artery Disease
المؤلفون المشاركون
Zhao, Yan
Xu, Zhengxi
Sun, Cheng
Si, Ke
Zheng, Zhe
Liu, Hanning
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-12-24
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Coronary artery disease (CAD) is the leading cause of mortality and morbidity worldwide.
Left main coronary artery disease (LMCAD) is a severe phenotype of CAD and has a genetic component.
Previous studies identified 3 inflammation-related single nucleotide polymorphisms (SNPs) contributing to the development of LMCAD.
We integrated these SNPs into a genetic risk score for the prediction of LMCAD.
We enrolled 1544 patients with CAD between 2007 and 2011.
The individual associations of the 3 SNPs with LMCAD were assessed.
We then calculated the genetic risk score for each patient and stratified patients into low-risk, intermediate-risk, and high-risk categories of genetic risk.
In univariable logistic regression analysis, the odds of LMCAD for the high-risk group were 2.81 (95% confidence interval [CI]: 1.72-4.60; P = 0.02) times those of the low-risk group.
After adjustment for CAD-related clinical variables, the high-risk group (adjusted OR: 2.78; 95% CI: 1.69-4.58; P = 0.02) had increased odds of LMCAD when compared with the low-risk group.
Comparison of model c-statistics showed greater predictive value with regard to LMCAD for the genetic risk score model than the models including single SNPs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xu, Zhengxi& Liu, Hanning& Sun, Cheng& Si, Ke& Zhao, Yan& Zheng, Zhe. 2018. Association between a Genetic Risk Score Based on Single Nucleotide Polymorphisms of Coronary Artery Disease-Related Genes and Left Main Coronary Artery Disease. BioMed Research International،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1129243
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xu, Zhengxi…[et al.]. Association between a Genetic Risk Score Based on Single Nucleotide Polymorphisms of Coronary Artery Disease-Related Genes and Left Main Coronary Artery Disease. BioMed Research International No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1129243
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xu, Zhengxi& Liu, Hanning& Sun, Cheng& Si, Ke& Zhao, Yan& Zheng, Zhe. Association between a Genetic Risk Score Based on Single Nucleotide Polymorphisms of Coronary Artery Disease-Related Genes and Left Main Coronary Artery Disease. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1129243
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1129243
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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