Association between a Genetic Risk Score Based on Single Nucleotide Polymorphisms of Coronary Artery Disease-Related Genes and Left Main Coronary Artery Disease

Abstract EN

Coronary artery disease (CAD) is the leading cause of mortality and morbidity worldwide.

Left main coronary artery disease (LMCAD) is a severe phenotype of CAD and has a genetic component.

Previous studies identified 3 inflammation-related single nucleotide polymorphisms (SNPs) contributing to the development of LMCAD.

We integrated these SNPs into a genetic risk score for the prediction of LMCAD.

We enrolled 1544 patients with CAD between 2007 and 2011.

The individual associations of the 3 SNPs with LMCAD were assessed.

We then calculated the genetic risk score for each patient and stratified patients into low-risk, intermediate-risk, and high-risk categories of genetic risk.

In univariable logistic regression analysis, the odds of LMCAD for the high-risk group were 2.81 (95% confidence interval [CI]: 1.72-4.60; P = 0.02) times those of the low-risk group.

After adjustment for CAD-related clinical variables, the high-risk group (adjusted OR: 2.78; 95% CI: 1.69-4.58; P = 0.02) had increased odds of LMCAD when compared with the low-risk group.

Comparison of model c-statistics showed greater predictive value with regard to LMCAD for the genetic risk score model than the models including single SNPs.