Stromal Cell-Derived Factor-1α Alleviates Calcium-Sensing Receptor Activation-Mediated IschemiaReperfusion Injury by Inhibiting Caspase-3Caspase-9-Induced Cell Apoptosis in Rat Free Flaps
المؤلفون المشاركون
Song, Li
Gao, Li-Na
Wang, Jun
Thapa, Swosti
Li, Yong
Zhong, Xiao-Bo
Zhao, Hong-Wei
Xiang, Xue-Rong
Zhang, Fu-Gui
Ji, Ping
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-01-11
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Surgical flaps are frequently affected by ischemia/reperfusion (I/R) injury.
Calcium-sensing receptor (CaSR) and stromal cell-derived factor-1α (SDF-1α) are closely associated with myocardial I/R injury.
This study was performed to evaluate the feasibility of applying SDF-1α to counteract CaSR activation-mediated I/R injury in ischemic free flaps.
Free flaps that underwent ischemia for 3 h were equally randomized into five groups: CaCl2, NPS2143 + CaCl2, SDF-1α + CaCl2, AMD3100 + SDF-1α + CaCl2, and normal saline.
The free flaps were harvested to evaluate flap necrosis and neovascularization after 2 h or 7 d of reperfusion.
p-CaSR/CaSR was extensively expressed in vascular endothelial cells of free flaps after I/R injury, and activation of the SDF-1α/CXCR4 axis and NPS2143 could reduce the expression of cleaved caspase-3, caspase-9, FAS, Cyt-c, and Bax and increase Bcl-2 expression; the opposite was true after CaSR activation.
Interestingly, initiation of the SDF-1α/CXCR4 axis might abrogate CaSR activation-induced I/R injury through enhancement of microvessel density.
In conclusion, CaSR might become a novel therapeutic target of free flaps affected by I/R injury.
Activation of the SDF-1α/CXCR4 axis and NPS2143 could counteract CaSR activation-mediated I/R injury and promote free flap survival through inhibition of caspase-3/caspase-9-related cell apoptosis and enhancement of neovascularization.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Song, Li& Gao, Li-Na& Wang, Jun& Thapa, Swosti& Li, Yong& Zhong, Xiao-Bo…[et al.]. 2018. Stromal Cell-Derived Factor-1α Alleviates Calcium-Sensing Receptor Activation-Mediated IschemiaReperfusion Injury by Inhibiting Caspase-3Caspase-9-Induced Cell Apoptosis in Rat Free Flaps. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1129401
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Song, Li…[et al.]. Stromal Cell-Derived Factor-1α Alleviates Calcium-Sensing Receptor Activation-Mediated IschemiaReperfusion Injury by Inhibiting Caspase-3Caspase-9-Induced Cell Apoptosis in Rat Free Flaps. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1129401
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Song, Li& Gao, Li-Na& Wang, Jun& Thapa, Swosti& Li, Yong& Zhong, Xiao-Bo…[et al.]. Stromal Cell-Derived Factor-1α Alleviates Calcium-Sensing Receptor Activation-Mediated IschemiaReperfusion Injury by Inhibiting Caspase-3Caspase-9-Induced Cell Apoptosis in Rat Free Flaps. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1129401
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1129401
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر