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In Silico Knockout Screening of Plasmodium falciparum Reactions and Prediction of Novel Essential Reactions by Analysing the Metabolic Network
المؤلفون المشاركون
Oyelade, Jelili
Isewon, Itunuoluwa
Uwoghiren, Efosa
Aromolaran, Olufemi
Oladipupo, Olufunke
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-29
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Malaria is an infectious disease that affects close to half a million individuals every year and Plasmodium falciparum is a major cause of malaria.
The treatment of this disease could be done effectively if the essential enzymes of this parasite are specifically targeted.
Nevertheless, the development of the parasite in resisting existing drugs now makes discovering new drugs a core responsibility.
In this study, a novel computational model that makes the prediction of new and validated antimalarial drug target cheaper, easier, and faster has been developed.
We have identified new essential reactions as potential targets for drugs in the metabolic network of the parasite.
Among the top seven (7) predicted essential reactions, four (4) have been previously identified in earlier studies with biological evidence and one (1) has been with computational evidence.
The results from our study were compared with an extensive list of seventy-seven (77) essential reactions with biological evidence from a previous study.
We present a list of thirty-one (31) potential candidates for drug targets in Plasmodium falciparum which includes twenty-four (24) new potential candidates for drug targets.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Oyelade, Jelili& Isewon, Itunuoluwa& Uwoghiren, Efosa& Aromolaran, Olufemi& Oladipupo, Olufunke. 2018. In Silico Knockout Screening of Plasmodium falciparum Reactions and Prediction of Novel Essential Reactions by Analysing the Metabolic Network. BioMed Research International،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1129425
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Oyelade, Jelili…[et al.]. In Silico Knockout Screening of Plasmodium falciparum Reactions and Prediction of Novel Essential Reactions by Analysing the Metabolic Network. BioMed Research International No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1129425
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Oyelade, Jelili& Isewon, Itunuoluwa& Uwoghiren, Efosa& Aromolaran, Olufemi& Oladipupo, Olufunke. In Silico Knockout Screening of Plasmodium falciparum Reactions and Prediction of Novel Essential Reactions by Analysing the Metabolic Network. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1129425
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1129425
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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