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In Silico Knockout Screening of Plasmodium falciparum Reactions and Prediction of Novel Essential Reactions by Analysing the Metabolic Network
Joint Authors
Oyelade, Jelili
Isewon, Itunuoluwa
Uwoghiren, Efosa
Aromolaran, Olufemi
Oladipupo, Olufunke
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-29
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Malaria is an infectious disease that affects close to half a million individuals every year and Plasmodium falciparum is a major cause of malaria.
The treatment of this disease could be done effectively if the essential enzymes of this parasite are specifically targeted.
Nevertheless, the development of the parasite in resisting existing drugs now makes discovering new drugs a core responsibility.
In this study, a novel computational model that makes the prediction of new and validated antimalarial drug target cheaper, easier, and faster has been developed.
We have identified new essential reactions as potential targets for drugs in the metabolic network of the parasite.
Among the top seven (7) predicted essential reactions, four (4) have been previously identified in earlier studies with biological evidence and one (1) has been with computational evidence.
The results from our study were compared with an extensive list of seventy-seven (77) essential reactions with biological evidence from a previous study.
We present a list of thirty-one (31) potential candidates for drug targets in Plasmodium falciparum which includes twenty-four (24) new potential candidates for drug targets.
American Psychological Association (APA)
Oyelade, Jelili& Isewon, Itunuoluwa& Uwoghiren, Efosa& Aromolaran, Olufemi& Oladipupo, Olufunke. 2018. In Silico Knockout Screening of Plasmodium falciparum Reactions and Prediction of Novel Essential Reactions by Analysing the Metabolic Network. BioMed Research International،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1129425
Modern Language Association (MLA)
Oyelade, Jelili…[et al.]. In Silico Knockout Screening of Plasmodium falciparum Reactions and Prediction of Novel Essential Reactions by Analysing the Metabolic Network. BioMed Research International No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1129425
American Medical Association (AMA)
Oyelade, Jelili& Isewon, Itunuoluwa& Uwoghiren, Efosa& Aromolaran, Olufemi& Oladipupo, Olufunke. In Silico Knockout Screening of Plasmodium falciparum Reactions and Prediction of Novel Essential Reactions by Analysing the Metabolic Network. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1129425
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129425