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Lenalidomide and Low Dose Dexamethasone Plus Elotuzumab or Carfilzomib for Relapsed or Refractory Multiple Myeloma: A Comparison of Progression-Free Survival with Reconstructed Individual Participant Data
المؤلفون المشاركون
Meng, Xiangyu
Li, Shuo
Maman, Souraka Tapara Dramani
Xiao, Yong-Nong
Li, Sheng
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-12-16
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Refractory and relapsed multiple myeloma (RRMM) remains a clinical challenge.
We compared the progression-free survival (PFS) of RRMM patients treated with lenalidomide and low dose dexamethasone plus elotuzumab or carfilzomib (ELD vs.
CLD), using reconstructed individual patient data (IPD) based on two published trials reports.
Methods.
We extracted data of study-level characteristics from original trial reports.
We evaluated the comparability between the two treatment groups in terms of baseline status.
Digitization of PFS Kaplan-Meier curves, reconstruction of IPD data, and subsequent survival analysis were performed.
Distribution of progression and death events over time was visualized as histograms and corresponding kernel density lines, and Kaplan-Meier survival curves were plotted.
Hazard ratio (HR) and corresponding 95% confidence interval (95% CI) were calculated.
Results.
Significant difference in race and disease stage distribution was found (P < 0.0001).
Higher proportion of white patients and patients with advanced disease in the carfilzomib group was identified.
Survival analysis revealed better PFS in the carfilzomib group (elotuzumab group vs.
carfilzomib group: HR = 1.36, 95% CI = [1.11-1.67]).
Conclusion.
The CLD regimen may result in better PFS as compared with the ELD regimen in RRMM patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Shuo& Meng, Xiangyu& Maman, Souraka Tapara Dramani& Xiao, Yong-Nong& Li, Sheng. 2018. Lenalidomide and Low Dose Dexamethasone Plus Elotuzumab or Carfilzomib for Relapsed or Refractory Multiple Myeloma: A Comparison of Progression-Free Survival with Reconstructed Individual Participant Data. BioMed Research International،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1129464
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Shuo…[et al.]. Lenalidomide and Low Dose Dexamethasone Plus Elotuzumab or Carfilzomib for Relapsed or Refractory Multiple Myeloma: A Comparison of Progression-Free Survival with Reconstructed Individual Participant Data. BioMed Research International No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1129464
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Shuo& Meng, Xiangyu& Maman, Souraka Tapara Dramani& Xiao, Yong-Nong& Li, Sheng. Lenalidomide and Low Dose Dexamethasone Plus Elotuzumab or Carfilzomib for Relapsed or Refractory Multiple Myeloma: A Comparison of Progression-Free Survival with Reconstructed Individual Participant Data. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1129464
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1129464
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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