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Lenalidomide and Low Dose Dexamethasone Plus Elotuzumab or Carfilzomib for Relapsed or Refractory Multiple Myeloma: A Comparison of Progression-Free Survival with Reconstructed Individual Participant Data
Joint Authors
Meng, Xiangyu
Li, Shuo
Maman, Souraka Tapara Dramani
Xiao, Yong-Nong
Li, Sheng
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Refractory and relapsed multiple myeloma (RRMM) remains a clinical challenge.
We compared the progression-free survival (PFS) of RRMM patients treated with lenalidomide and low dose dexamethasone plus elotuzumab or carfilzomib (ELD vs.
CLD), using reconstructed individual patient data (IPD) based on two published trials reports.
Methods.
We extracted data of study-level characteristics from original trial reports.
We evaluated the comparability between the two treatment groups in terms of baseline status.
Digitization of PFS Kaplan-Meier curves, reconstruction of IPD data, and subsequent survival analysis were performed.
Distribution of progression and death events over time was visualized as histograms and corresponding kernel density lines, and Kaplan-Meier survival curves were plotted.
Hazard ratio (HR) and corresponding 95% confidence interval (95% CI) were calculated.
Results.
Significant difference in race and disease stage distribution was found (P < 0.0001).
Higher proportion of white patients and patients with advanced disease in the carfilzomib group was identified.
Survival analysis revealed better PFS in the carfilzomib group (elotuzumab group vs.
carfilzomib group: HR = 1.36, 95% CI = [1.11-1.67]).
Conclusion.
The CLD regimen may result in better PFS as compared with the ELD regimen in RRMM patients.
American Psychological Association (APA)
Li, Shuo& Meng, Xiangyu& Maman, Souraka Tapara Dramani& Xiao, Yong-Nong& Li, Sheng. 2018. Lenalidomide and Low Dose Dexamethasone Plus Elotuzumab or Carfilzomib for Relapsed or Refractory Multiple Myeloma: A Comparison of Progression-Free Survival with Reconstructed Individual Participant Data. BioMed Research International،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1129464
Modern Language Association (MLA)
Li, Shuo…[et al.]. Lenalidomide and Low Dose Dexamethasone Plus Elotuzumab or Carfilzomib for Relapsed or Refractory Multiple Myeloma: A Comparison of Progression-Free Survival with Reconstructed Individual Participant Data. BioMed Research International No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1129464
American Medical Association (AMA)
Li, Shuo& Meng, Xiangyu& Maman, Souraka Tapara Dramani& Xiao, Yong-Nong& Li, Sheng. Lenalidomide and Low Dose Dexamethasone Plus Elotuzumab or Carfilzomib for Relapsed or Refractory Multiple Myeloma: A Comparison of Progression-Free Survival with Reconstructed Individual Participant Data. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1129464
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129464