The Evaluation of ProanthocyanidinsChitosanLecithin Microspheres as Sustained Drug Delivery System
المؤلفون المشاركون
Zhang, Weifen
Yu, Hong-Li
Feng, Zhan-Qin
Zhang, Jing-Jing
Wang, Yong-Hong
Ding, De-Jun
Gao, Yuan-Yuan
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-24
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Proanthocyanidin (PC) has attracted wide attention on cosmetics and pharmaceutical due to its antioxidant, anticancer, antimicrobial, antiangiogenic, and anti-inflammatory activities.
However, PC applications are limited because of its sensitivity to thermal treatment, light, and oxidation and the poor absorption in the gastrointestinal tract.
Thus, a novel dosage form of PC needs to be designed to improve its stability and bioavailability for drug delivery.
The objective of this study is to fabricate proanthocyanidins/chitosan/lecithin (PC/CTS/LEC) microspheres and investigate various characteristics.
In the current study, PC/CTS/LEC microspheres were prepared by spray-drying technology.
The yield (61.68%), encapsulation efficiency (68.19%), and drug loading capacity (17.05%) were found in the results.
The scanning electron microscope demonstrated that the microspheres were spherical in shape with wrinkled surfaces.
DSC study displayed that the microspheres stability was greatly improved when comparing with bare PC.
The in vitro release study showed that the 76.92% of PC was released from microspheres within 48 h.
The moisture contents of microspheres ranged from 8% to 13%.
The swelling rate and tapped density of microspheres were elevated with increasing the concentration of chitosan in the formulations.
The moisture uptake of microspheres was saturated at 40°C/RH75% within 12 h.
Our results indicated that the stability of PC/CTS/LEC microspheres was enhanced, and it is a promising carrier for sustained drug delivery system.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yu, Hong-Li& Feng, Zhan-Qin& Zhang, Jing-Jing& Wang, Yong-Hong& Ding, De-Jun& Gao, Yuan-Yuan…[et al.]. 2018. The Evaluation of ProanthocyanidinsChitosanLecithin Microspheres as Sustained Drug Delivery System. BioMed Research International،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1129481
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yu, Hong-Li…[et al.]. The Evaluation of ProanthocyanidinsChitosanLecithin Microspheres as Sustained Drug Delivery System. BioMed Research International No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1129481
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yu, Hong-Li& Feng, Zhan-Qin& Zhang, Jing-Jing& Wang, Yong-Hong& Ding, De-Jun& Gao, Yuan-Yuan…[et al.]. The Evaluation of ProanthocyanidinsChitosanLecithin Microspheres as Sustained Drug Delivery System. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1129481
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1129481
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر