The Evaluation of ProanthocyanidinsChitosanLecithin Microspheres as Sustained Drug Delivery System

Joint Authors

Zhang, Weifen
Yu, Hong-Li
Feng, Zhan-Qin
Zhang, Jing-Jing
Wang, Yong-Hong
Ding, De-Jun
Gao, Yuan-Yuan

Source

BioMed Research International

Issue

Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2018-07-24

Country of Publication

Egypt

No. of Pages

11

Main Subjects

Medicine

Abstract EN

Proanthocyanidin (PC) has attracted wide attention on cosmetics and pharmaceutical due to its antioxidant, anticancer, antimicrobial, antiangiogenic, and anti-inflammatory activities.

However, PC applications are limited because of its sensitivity to thermal treatment, light, and oxidation and the poor absorption in the gastrointestinal tract.

Thus, a novel dosage form of PC needs to be designed to improve its stability and bioavailability for drug delivery.

The objective of this study is to fabricate proanthocyanidins/chitosan/lecithin (PC/CTS/LEC) microspheres and investigate various characteristics.

In the current study, PC/CTS/LEC microspheres were prepared by spray-drying technology.

The yield (61.68%), encapsulation efficiency (68.19%), and drug loading capacity (17.05%) were found in the results.

The scanning electron microscope demonstrated that the microspheres were spherical in shape with wrinkled surfaces.

DSC study displayed that the microspheres stability was greatly improved when comparing with bare PC.

The in vitro release study showed that the 76.92% of PC was released from microspheres within 48 h.

The moisture contents of microspheres ranged from 8% to 13%.

The swelling rate and tapped density of microspheres were elevated with increasing the concentration of chitosan in the formulations.

The moisture uptake of microspheres was saturated at 40°C/RH75% within 12 h.

Our results indicated that the stability of PC/CTS/LEC microspheres was enhanced, and it is a promising carrier for sustained drug delivery system.

American Psychological Association (APA)

Yu, Hong-Li& Feng, Zhan-Qin& Zhang, Jing-Jing& Wang, Yong-Hong& Ding, De-Jun& Gao, Yuan-Yuan…[et al.]. 2018. The Evaluation of ProanthocyanidinsChitosanLecithin Microspheres as Sustained Drug Delivery System. BioMed Research International،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1129481

Modern Language Association (MLA)

Yu, Hong-Li…[et al.]. The Evaluation of ProanthocyanidinsChitosanLecithin Microspheres as Sustained Drug Delivery System. BioMed Research International No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1129481

American Medical Association (AMA)

Yu, Hong-Li& Feng, Zhan-Qin& Zhang, Jing-Jing& Wang, Yong-Hong& Ding, De-Jun& Gao, Yuan-Yuan…[et al.]. The Evaluation of ProanthocyanidinsChitosanLecithin Microspheres as Sustained Drug Delivery System. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1129481

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1129481