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A Novel Fragment Derived from Laminin-411 Facilitates Proliferation and Differentiation of Odontoblast-Like Cells
المؤلفون المشاركون
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-05-09
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The aim for the present study was to evaluate the in vitro effects of iMatrix-411 in odontoblast-like cells.
To that end, iMatrix-411 was coated to both nontissue culture treated- (Non-PS) and tissue culture treated-polystyrene (TCPS) multiwells.
MDPC-23 cells were seeded into noncoated (control) or coated wells.
Optimal coating density and cell proliferation were assessed by cell counting kit-8 (CCK-8) at day two, day three, and day five.
Osteo/odontogenic differentiation was evaluated by real-time RT-PCR and alkaline phosphatase (ALP) activity at days seven and eight, respectively.
Calcific deposition of cells was visualized by alizarin red staining.
Data were analyzed with post hoc Tukey HSD test (p<0.05).
Optimal coating density for iMatrix-411 was 8 μg/cm2.
Exposure of MDPC-23 cells to iMatrix-411 in either non-PS or TCPS significantly enhanced proliferative activity.
iMatrix-411 elevated ALP activity in both types of culture plates.
iMatrix-411 significantly increased the mRNA level of OCN, BSP, OPN, ALP, and DMP-1.
Meanwhile, it enhanced the expression of several integrin subunits: ITGA1, ITGA5, ITGAV, ITGB1, and ITGB5.
Finally, iMatrix-411 also accelerated the mineralization at day eight in Non-PS.
The results indicated iMatrix-411 stimulates proliferation and favours differentiation of odontoblast-like cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tang, Jia& Saito, Takashi. 2018. A Novel Fragment Derived from Laminin-411 Facilitates Proliferation and Differentiation of Odontoblast-Like Cells. BioMed Research International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1129773
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tang, Jia& Saito, Takashi. A Novel Fragment Derived from Laminin-411 Facilitates Proliferation and Differentiation of Odontoblast-Like Cells. BioMed Research International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1129773
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tang, Jia& Saito, Takashi. A Novel Fragment Derived from Laminin-411 Facilitates Proliferation and Differentiation of Odontoblast-Like Cells. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1129773
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1129773
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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