Impact of Chronic Statins Use on the Development of Esophagitis in Patients with Gastroesophageal Reflux Disease
المؤلفون المشاركون
Khoury, Tawfik
Watad, Abdulla
Sbeit, Wisam
Mari, Amir
Mahamid, Mahmud
Amara, Hana
Jabaren, Mohamed
Nseir, Wiliam
المصدر
Canadian Journal of Gastroenterology and Hepatology
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-02-03
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background and Aims.
We aimed to assess whether chronic statins used (> 6 months) were protective of the development of esophagitis in patients with gastroesophageal reflux disease.
In the presence of esophagitis, complications such as strictures, Barrett's esophagus, and adenocarcinoma were the most common.
Statins, lipid lowering drugs with a pleiotropic effect, are recently implicated in various pathologies.
Nevertheless, the possible impact of statins in esophagitis development has never been assessed.
Methods.
We performed a retrospective, cross-sectional, single center study that included 4148 gastroesophageal reflux disease patients from 2014 and 2018 at EMMS Nazareth Hospital.
We divided the patients into 5 groups.
The groups were split into positive control group, which was the nonesophagitis group, and the other 4 groups were A-D (as per Los Angeles classification).
Results.
Overall, out of the 4148 patients included, 48% were males and 2840 patients were in the control group.
In groups A, B, C, and D there were 818, 402, 72, and 16 patients, respectively.
Logistic regression analysis revealed that chronic statins usage is protective by preventing development esophagitis (OR 0.463 [95%CI 0.370–0.579], p < 0.0001).
NSAIDS use, Hiatus hernia, and H.
pylori were promoting factors (OR, 1.362, 1.779, and 1.811; 95% CI, 1.183-1.569, 1.551-2.040, and 1.428-2.298; P<0.0001, P<0.0001, and P<0.0001, respectively).
Conclusion.
Using chronic statins was protective to the development of esophagitis among GERD patients.
Our findings of potential clinical application mandate further randomized controlled trials to better assess the impact of statins on esophagitis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Khoury, Tawfik& Mari, Amir& Amara, Hana& Jabaren, Mohamed& Watad, Abdulla& Nseir, Wiliam…[et al.]. 2019. Impact of Chronic Statins Use on the Development of Esophagitis in Patients with Gastroesophageal Reflux Disease. Canadian Journal of Gastroenterology and Hepatology،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1129891
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Khoury, Tawfik…[et al.]. Impact of Chronic Statins Use on the Development of Esophagitis in Patients with Gastroesophageal Reflux Disease. Canadian Journal of Gastroenterology and Hepatology No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1129891
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Khoury, Tawfik& Mari, Amir& Amara, Hana& Jabaren, Mohamed& Watad, Abdulla& Nseir, Wiliam…[et al.]. Impact of Chronic Statins Use on the Development of Esophagitis in Patients with Gastroesophageal Reflux Disease. Canadian Journal of Gastroenterology and Hepatology. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1129891
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1129891
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر