Impact of Chronic Statins Use on the Development of Esophagitis in Patients with Gastroesophageal Reflux Disease
Joint Authors
Khoury, Tawfik
Watad, Abdulla
Sbeit, Wisam
Mari, Amir
Mahamid, Mahmud
Amara, Hana
Jabaren, Mohamed
Nseir, Wiliam
Source
Canadian Journal of Gastroenterology and Hepatology
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background and Aims.
We aimed to assess whether chronic statins used (> 6 months) were protective of the development of esophagitis in patients with gastroesophageal reflux disease.
In the presence of esophagitis, complications such as strictures, Barrett's esophagus, and adenocarcinoma were the most common.
Statins, lipid lowering drugs with a pleiotropic effect, are recently implicated in various pathologies.
Nevertheless, the possible impact of statins in esophagitis development has never been assessed.
Methods.
We performed a retrospective, cross-sectional, single center study that included 4148 gastroesophageal reflux disease patients from 2014 and 2018 at EMMS Nazareth Hospital.
We divided the patients into 5 groups.
The groups were split into positive control group, which was the nonesophagitis group, and the other 4 groups were A-D (as per Los Angeles classification).
Results.
Overall, out of the 4148 patients included, 48% were males and 2840 patients were in the control group.
In groups A, B, C, and D there were 818, 402, 72, and 16 patients, respectively.
Logistic regression analysis revealed that chronic statins usage is protective by preventing development esophagitis (OR 0.463 [95%CI 0.370–0.579], p < 0.0001).
NSAIDS use, Hiatus hernia, and H.
pylori were promoting factors (OR, 1.362, 1.779, and 1.811; 95% CI, 1.183-1.569, 1.551-2.040, and 1.428-2.298; P<0.0001, P<0.0001, and P<0.0001, respectively).
Conclusion.
Using chronic statins was protective to the development of esophagitis among GERD patients.
Our findings of potential clinical application mandate further randomized controlled trials to better assess the impact of statins on esophagitis.
American Psychological Association (APA)
Khoury, Tawfik& Mari, Amir& Amara, Hana& Jabaren, Mohamed& Watad, Abdulla& Nseir, Wiliam…[et al.]. 2019. Impact of Chronic Statins Use on the Development of Esophagitis in Patients with Gastroesophageal Reflux Disease. Canadian Journal of Gastroenterology and Hepatology،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1129891
Modern Language Association (MLA)
Khoury, Tawfik…[et al.]. Impact of Chronic Statins Use on the Development of Esophagitis in Patients with Gastroesophageal Reflux Disease. Canadian Journal of Gastroenterology and Hepatology No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1129891
American Medical Association (AMA)
Khoury, Tawfik& Mari, Amir& Amara, Hana& Jabaren, Mohamed& Watad, Abdulla& Nseir, Wiliam…[et al.]. Impact of Chronic Statins Use on the Development of Esophagitis in Patients with Gastroesophageal Reflux Disease. Canadian Journal of Gastroenterology and Hepatology. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1129891
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129891