Salivary MicroRNAs for Early Detection of Head and Neck Squamous Cell Carcinoma: A Case-Control Study in the High Altitude Mestizo Ecuadorian Population
المؤلفون المشاركون
García-Cárdenas, Jennyfer M.
Guevara-Ramírez, Patricia
López-Cortés, Andrés
Leone, Paola E.
Paz-y-Miño, César
Salazar-Ruales, Carolina
Arguello, Jessica-Viviana
Cabrera-Andrade, Alejandro
Peralta, Patricio
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-11-21
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer with the highest incidence worldwide.
HNSCC is often diagnosed at advanced stages, incurring significant high mortality and morbidity.
The use of saliva, as a noninvasive tool for the diagnosis of cancer, has recently increased.
Salivary microRNAs (miRNAs) have emerged as a promising molecular tool for early diagnosis of HNSCC.
The aim was to identify the differential expression of salivary miRNAs associated with HNSCC in the high altitude mestizo Ecuadorian population.
Using PCR Arrays, miR-122-5p, miR-92a-3p, miR-124-3p, miR-205-5p, and miR-146a-5p were found as the most representative ones.
Subsequently, miRNAs expression was confirmed in saliva samples from 108 cases and 108 controls.
miR-122-5p, miR-92a-3p, miR-124-3p, and miR-146a-5p showed significant statistical difference between cases and controls with areas under the curve (AUC) of 0.73 (p < 0.001), 0.70 (p < 0.001), 0.71 (p = 0.002), and 0.66 (p = 0.008), respectively.
miRNAs were also deregulated in between HNSCC localizations.
A differentiated expression of miR-122-5p between oral cancer and oropharynx cancer (AUC of 0.96 p = 0.01) was found: miR-124-3p between larynx and pharynx (AUC = 0.97, p < 0.01) and miR-146a-5p between larynx, oropharynx, and oral cavity (AUC = 0.96, p = 0.01).
Moreover, miR-122-5p, miR-124-3p, miR-205-5p, and miR-146a-5p could differentiate between HPV+ and HPV- (p=0.004).
Finally, the expression profiles of the five miRNAs were evaluated to discriminate HNSCC patient’s tumor stages (TNM 2-4).
miR-122-5p differentiates TNM 2 and 3 (p = 0.002, AUC = 0.92), miR-124-3p TNM 2, 3, and 4 (p < 0.001, AUC = 98), miR-146a-5p TNM 2 and 3 (p < 0.001, AUC = 0.97), and miR-92a-3p TNM 3 (p < 0.001, AUC = 0.99).
Taken together, these findings show that altered expression of miRNAs could be used as biomarkers for HNSCC diagnosis in the high altitude mestizo Ecuadorian population.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Salazar-Ruales, Carolina& Arguello, Jessica-Viviana& López-Cortés, Andrés& Cabrera-Andrade, Alejandro& García-Cárdenas, Jennyfer M.& Guevara-Ramírez, Patricia…[et al.]. 2018. Salivary MicroRNAs for Early Detection of Head and Neck Squamous Cell Carcinoma: A Case-Control Study in the High Altitude Mestizo Ecuadorian Population. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1130024
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Salazar-Ruales, Carolina…[et al.]. Salivary MicroRNAs for Early Detection of Head and Neck Squamous Cell Carcinoma: A Case-Control Study in the High Altitude Mestizo Ecuadorian Population. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1130024
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Salazar-Ruales, Carolina& Arguello, Jessica-Viviana& López-Cortés, Andrés& Cabrera-Andrade, Alejandro& García-Cárdenas, Jennyfer M.& Guevara-Ramírez, Patricia…[et al.]. Salivary MicroRNAs for Early Detection of Head and Neck Squamous Cell Carcinoma: A Case-Control Study in the High Altitude Mestizo Ecuadorian Population. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1130024
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1130024
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر