Protective Role of Picralima nitida Seed Extract in High-Fat High-Fructose-Fed Rats
المؤلفون المشاركون
De Campos, Opeyemi Christianah
Osaigbovo, Daniel Ikpomwosa
Bisi-Adeniyi, Titilayo Ifeoluwa
Iheagwam, Franklyn Nonso
Rotimi, Solomon Oladapo
Chinedu, Shalom Nwodo
المصدر
Advances in Pharmacological and Pharmaceutical Sciences
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-24
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Picralima nitida is a therapeutic herb used in ethnomedicine for the management of several disease conditions including diabetes.
This study examined the potential palliative effect of aqueous seed extract of Picralima nitida (APN) on dyslipidemia, hyperglycemia, oxidative stress, insulin resistance, and the expression of some metabolic genes in high-fat high-fructose-fed rats.
Experimental rats (2 months old) were fed a control diet or a high-fat diet with 25% fructose (HFHF diet) in their drinking water for nine weeks.
APN was administered orally during the last four weeks.
Anthropometric and antioxidant parameters, lipid profile, plasma glucose, and insulin levels and the relative expression of some metabolic genes were assessed.
APN caused a significant decrease (P<0.05) in weight gained, body mass index, insulin resistance, plasma glucose, and insulin levels.
High-density lipoprotein cholesterol level was significantly increased (P<0.05), while triacylglycerol, cholesterol, low-density lipoprotein, cardiac index, atherogenic index, coronary artery index, and malondialdehyde levels in plasma and liver samples were also significantly decreased (P<0.05) by APN at all experimental doses when compared to the group fed with an HFHF diet only.
APN also significantly (P<0.05) upregulated the relative expression of glucokinase, carnitine palmitoyltransferase-1 (CPT-1), and leptin at 400 mg/kg body weight when compared to the group fed with an HFHF diet only.
This study showed that APN alleviated dyslipidemia, hyperglycemia, and oxidant effect associated with the intake of a high-fat high-fructose diet.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
De Campos, Opeyemi Christianah& Osaigbovo, Daniel Ikpomwosa& Bisi-Adeniyi, Titilayo Ifeoluwa& Iheagwam, Franklyn Nonso& Rotimi, Solomon Oladapo& Chinedu, Shalom Nwodo. 2020. Protective Role of Picralima nitida Seed Extract in High-Fat High-Fructose-Fed Rats. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1130096
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
De Campos, Opeyemi Christianah…[et al.]. Protective Role of Picralima nitida Seed Extract in High-Fat High-Fructose-Fed Rats. Advances in Pharmacological and Pharmaceutical Sciences No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1130096
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
De Campos, Opeyemi Christianah& Osaigbovo, Daniel Ikpomwosa& Bisi-Adeniyi, Titilayo Ifeoluwa& Iheagwam, Franklyn Nonso& Rotimi, Solomon Oladapo& Chinedu, Shalom Nwodo. Protective Role of Picralima nitida Seed Extract in High-Fat High-Fructose-Fed Rats. Advances in Pharmacological and Pharmaceutical Sciences. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1130096
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1130096
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر