Protective Role of Picralima nitida Seed Extract in High-Fat High-Fructose-Fed Rats
Joint Authors
De Campos, Opeyemi Christianah
Osaigbovo, Daniel Ikpomwosa
Bisi-Adeniyi, Titilayo Ifeoluwa
Iheagwam, Franklyn Nonso
Rotimi, Solomon Oladapo
Chinedu, Shalom Nwodo
Source
Advances in Pharmacological and Pharmaceutical Sciences
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-24
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Picralima nitida is a therapeutic herb used in ethnomedicine for the management of several disease conditions including diabetes.
This study examined the potential palliative effect of aqueous seed extract of Picralima nitida (APN) on dyslipidemia, hyperglycemia, oxidative stress, insulin resistance, and the expression of some metabolic genes in high-fat high-fructose-fed rats.
Experimental rats (2 months old) were fed a control diet or a high-fat diet with 25% fructose (HFHF diet) in their drinking water for nine weeks.
APN was administered orally during the last four weeks.
Anthropometric and antioxidant parameters, lipid profile, plasma glucose, and insulin levels and the relative expression of some metabolic genes were assessed.
APN caused a significant decrease (P<0.05) in weight gained, body mass index, insulin resistance, plasma glucose, and insulin levels.
High-density lipoprotein cholesterol level was significantly increased (P<0.05), while triacylglycerol, cholesterol, low-density lipoprotein, cardiac index, atherogenic index, coronary artery index, and malondialdehyde levels in plasma and liver samples were also significantly decreased (P<0.05) by APN at all experimental doses when compared to the group fed with an HFHF diet only.
APN also significantly (P<0.05) upregulated the relative expression of glucokinase, carnitine palmitoyltransferase-1 (CPT-1), and leptin at 400 mg/kg body weight when compared to the group fed with an HFHF diet only.
This study showed that APN alleviated dyslipidemia, hyperglycemia, and oxidant effect associated with the intake of a high-fat high-fructose diet.
American Psychological Association (APA)
De Campos, Opeyemi Christianah& Osaigbovo, Daniel Ikpomwosa& Bisi-Adeniyi, Titilayo Ifeoluwa& Iheagwam, Franklyn Nonso& Rotimi, Solomon Oladapo& Chinedu, Shalom Nwodo. 2020. Protective Role of Picralima nitida Seed Extract in High-Fat High-Fructose-Fed Rats. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1130096
Modern Language Association (MLA)
De Campos, Opeyemi Christianah…[et al.]. Protective Role of Picralima nitida Seed Extract in High-Fat High-Fructose-Fed Rats. Advances in Pharmacological and Pharmaceutical Sciences No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1130096
American Medical Association (AMA)
De Campos, Opeyemi Christianah& Osaigbovo, Daniel Ikpomwosa& Bisi-Adeniyi, Titilayo Ifeoluwa& Iheagwam, Franklyn Nonso& Rotimi, Solomon Oladapo& Chinedu, Shalom Nwodo. Protective Role of Picralima nitida Seed Extract in High-Fat High-Fructose-Fed Rats. Advances in Pharmacological and Pharmaceutical Sciences. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1130096
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130096