Quantitative Anti-HBc in Liver Pathological States in Patients with Chronic Hepatitis B Virus Infection
المؤلفون المشاركون
Zhang, Zhan-qing
Shi, Bi-sheng
Lu, Wei
Liu, Dan-ping
Huang, Dan
Feng, Yan-ling
المصدر
Canadian Journal of Infectious Diseases and Medical Microbiology
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-27
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Background.
Changes of hepatitis B core antigen antibody (anti-HBc) in liver pathological involvement in patients with chronic hepatitis B virus (HBV) infection have not been investigated in detail.
This study aimed to explore evolving patterns of anti-HBc following liver pathological states and to investigate validities of anti-HBc for predicting liver pathological states.
Methods.
254 HBeAg-positive and 237 HBeAg-negative patients with chronic HBV infection were enrolled.
Liver pathological diagnoses referred to Scheuer standard, and anti-HBc was measured using chemiluminescence microparticle immunoassay.
Results.
Anti-HBc was significantly positively correlated with pathological grades and stages in both HBeAg-positive (rs = 0.312, P<0.0001, and rs = 0.268, P<0.0001) and HBeAg-negative (rs = 0.270, P<0.0001, and rs = 0.147, P=0.0237) patients.
The medians of anti-HBc in pathological grades of G1, G2, and G3 and stages of S1, S2, S3, and S4 in HBeAg-positive patients were all significantly lower than those in HBeAg-negative patients (all P<0.005).
The areas under receiver-operating characteristic curves (95% confidence interval) of anti-HBc for predicting pathological grades ≥G2 and ≥G3, and stages ≥S2 and =S4 in HBeAg-positive patients were 0.683 (0.622–0.740) and 0.662 (0.601–0.720), and 0.627 (0.564–0.687) and 0.683 (0.622–0.740), respectively, and in HBeAg-negative patients were 0.681 (0.618–0.740) and 0.702 (0.639–0.760), and 0.569 (0.503–0.633) and 0.630 (0.565–0.691), respectively.
Conclusion.
Following hepatic aggravation of necroinflammation and progression of fibrosis, anti-HBc increases gradually in HBeAg-positive patients and continues to increase gradually in HBeAg-negative patients, which is a useful but unsatisfactory marker for monitoring pathological states.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Zhan-qing& Shi, Bi-sheng& Lu, Wei& Liu, Dan-ping& Huang, Dan& Feng, Yan-ling. 2019. Quantitative Anti-HBc in Liver Pathological States in Patients with Chronic Hepatitis B Virus Infection. Canadian Journal of Infectious Diseases and Medical Microbiology،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1130099
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Zhan-qing…[et al.]. Quantitative Anti-HBc in Liver Pathological States in Patients with Chronic Hepatitis B Virus Infection. Canadian Journal of Infectious Diseases and Medical Microbiology No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1130099
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Zhan-qing& Shi, Bi-sheng& Lu, Wei& Liu, Dan-ping& Huang, Dan& Feng, Yan-ling. Quantitative Anti-HBc in Liver Pathological States in Patients with Chronic Hepatitis B Virus Infection. Canadian Journal of Infectious Diseases and Medical Microbiology. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1130099
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1130099
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر