Quantitative Anti-HBc in Liver Pathological States in Patients with Chronic Hepatitis B Virus Infection
Joint Authors
Zhang, Zhan-qing
Shi, Bi-sheng
Lu, Wei
Liu, Dan-ping
Huang, Dan
Feng, Yan-ling
Source
Canadian Journal of Infectious Diseases and Medical Microbiology
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-27
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Background.
Changes of hepatitis B core antigen antibody (anti-HBc) in liver pathological involvement in patients with chronic hepatitis B virus (HBV) infection have not been investigated in detail.
This study aimed to explore evolving patterns of anti-HBc following liver pathological states and to investigate validities of anti-HBc for predicting liver pathological states.
Methods.
254 HBeAg-positive and 237 HBeAg-negative patients with chronic HBV infection were enrolled.
Liver pathological diagnoses referred to Scheuer standard, and anti-HBc was measured using chemiluminescence microparticle immunoassay.
Results.
Anti-HBc was significantly positively correlated with pathological grades and stages in both HBeAg-positive (rs = 0.312, P<0.0001, and rs = 0.268, P<0.0001) and HBeAg-negative (rs = 0.270, P<0.0001, and rs = 0.147, P=0.0237) patients.
The medians of anti-HBc in pathological grades of G1, G2, and G3 and stages of S1, S2, S3, and S4 in HBeAg-positive patients were all significantly lower than those in HBeAg-negative patients (all P<0.005).
The areas under receiver-operating characteristic curves (95% confidence interval) of anti-HBc for predicting pathological grades ≥G2 and ≥G3, and stages ≥S2 and =S4 in HBeAg-positive patients were 0.683 (0.622–0.740) and 0.662 (0.601–0.720), and 0.627 (0.564–0.687) and 0.683 (0.622–0.740), respectively, and in HBeAg-negative patients were 0.681 (0.618–0.740) and 0.702 (0.639–0.760), and 0.569 (0.503–0.633) and 0.630 (0.565–0.691), respectively.
Conclusion.
Following hepatic aggravation of necroinflammation and progression of fibrosis, anti-HBc increases gradually in HBeAg-positive patients and continues to increase gradually in HBeAg-negative patients, which is a useful but unsatisfactory marker for monitoring pathological states.
American Psychological Association (APA)
Zhang, Zhan-qing& Shi, Bi-sheng& Lu, Wei& Liu, Dan-ping& Huang, Dan& Feng, Yan-ling. 2019. Quantitative Anti-HBc in Liver Pathological States in Patients with Chronic Hepatitis B Virus Infection. Canadian Journal of Infectious Diseases and Medical Microbiology،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1130099
Modern Language Association (MLA)
Zhang, Zhan-qing…[et al.]. Quantitative Anti-HBc in Liver Pathological States in Patients with Chronic Hepatitis B Virus Infection. Canadian Journal of Infectious Diseases and Medical Microbiology No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1130099
American Medical Association (AMA)
Zhang, Zhan-qing& Shi, Bi-sheng& Lu, Wei& Liu, Dan-ping& Huang, Dan& Feng, Yan-ling. Quantitative Anti-HBc in Liver Pathological States in Patients with Chronic Hepatitis B Virus Infection. Canadian Journal of Infectious Diseases and Medical Microbiology. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1130099
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130099