Hypertriglyceridemia Is Associated with Reduced Leukoaraiosis Severity in Patients with a Small Vessel Stroke

المؤلفون المشاركون

Ke, Daqiang
Zhou, Feng
Liang, Hui
Lou, Haiyan
Xu, Yang

المصدر

Behavioural Neurology

العدد

المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-5، 5ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2018-08-09

دولة النشر

مصر

عدد الصفحات

5

التخصصات الرئيسية

الأحياء
الطب البشري

الملخص EN

Intracranial hemorrhage or microbleeds and leukoaraiosis have an overlap in biology.

Hyperlipidemia may reduce the risk of ICH or cerebral microbleeds; studies focusing on the relationship between different lipid profiles and severity of periventricular hyperintensities (PVH) and subcortical white matter lesions (SWMLs) in the cerebral small vessel disease are limited.

Methods.

Patients with recent first lacunar infarct were recruited.

PVH and SWMLs were accessed on MRI with the Fazekas scale, and lipid levels were measured.

Univariate and multivariable regression analyses were used to assess the relation between different lipid profiles and severity of PVH and SWMLs.

Results.

In univariate analyses, advancing age was correlated with increasing severity of leukoaraiosis (P<0.001).

There was an inverse relationship between hypertriglyceridemia (hyper-TG) (≥1.7 mmol/l) and severity of leukoaraiosis (P<0.05).

In the multivariable analysis, after controlling for age, sex, and significant risk factors in the univariate and age-adjusted analyses, hyper-TG demonstrated a protective effect on the severity of PVH and SWMLs (P<0.05).

Higher total cholesterol (TC), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) were not associated with leukoaraiosis.

Conclusions.

Hyper-TG is associated with the severity of leukoaraiosis independent of other risk factors, and it might be a protective role in cerebral small vessel disease.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Ke, Daqiang& Zhou, Feng& Liang, Hui& Xu, Yang& Lou, Haiyan. 2018. Hypertriglyceridemia Is Associated with Reduced Leukoaraiosis Severity in Patients with a Small Vessel Stroke. Behavioural Neurology،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1130145

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Ke, Daqiang…[et al.]. Hypertriglyceridemia Is Associated with Reduced Leukoaraiosis Severity in Patients with a Small Vessel Stroke. Behavioural Neurology No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1130145

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Ke, Daqiang& Zhou, Feng& Liang, Hui& Xu, Yang& Lou, Haiyan. Hypertriglyceridemia Is Associated with Reduced Leukoaraiosis Severity in Patients with a Small Vessel Stroke. Behavioural Neurology. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1130145

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1130145