Hypertriglyceridemia Is Associated with Reduced Leukoaraiosis Severity in Patients with a Small Vessel Stroke
Joint Authors
Ke, Daqiang
Zhou, Feng
Liang, Hui
Lou, Haiyan
Xu, Yang
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-09
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Intracranial hemorrhage or microbleeds and leukoaraiosis have an overlap in biology.
Hyperlipidemia may reduce the risk of ICH or cerebral microbleeds; studies focusing on the relationship between different lipid profiles and severity of periventricular hyperintensities (PVH) and subcortical white matter lesions (SWMLs) in the cerebral small vessel disease are limited.
Methods.
Patients with recent first lacunar infarct were recruited.
PVH and SWMLs were accessed on MRI with the Fazekas scale, and lipid levels were measured.
Univariate and multivariable regression analyses were used to assess the relation between different lipid profiles and severity of PVH and SWMLs.
Results.
In univariate analyses, advancing age was correlated with increasing severity of leukoaraiosis (P<0.001).
There was an inverse relationship between hypertriglyceridemia (hyper-TG) (≥1.7 mmol/l) and severity of leukoaraiosis (P<0.05).
In the multivariable analysis, after controlling for age, sex, and significant risk factors in the univariate and age-adjusted analyses, hyper-TG demonstrated a protective effect on the severity of PVH and SWMLs (P<0.05).
Higher total cholesterol (TC), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) were not associated with leukoaraiosis.
Conclusions.
Hyper-TG is associated with the severity of leukoaraiosis independent of other risk factors, and it might be a protective role in cerebral small vessel disease.
American Psychological Association (APA)
Ke, Daqiang& Zhou, Feng& Liang, Hui& Xu, Yang& Lou, Haiyan. 2018. Hypertriglyceridemia Is Associated with Reduced Leukoaraiosis Severity in Patients with a Small Vessel Stroke. Behavioural Neurology،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1130145
Modern Language Association (MLA)
Ke, Daqiang…[et al.]. Hypertriglyceridemia Is Associated with Reduced Leukoaraiosis Severity in Patients with a Small Vessel Stroke. Behavioural Neurology No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1130145
American Medical Association (AMA)
Ke, Daqiang& Zhou, Feng& Liang, Hui& Xu, Yang& Lou, Haiyan. Hypertriglyceridemia Is Associated with Reduced Leukoaraiosis Severity in Patients with a Small Vessel Stroke. Behavioural Neurology. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1130145
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130145