Assessment of Intratumoral Doxorubicin Penetration after Mild Hyperthermia-Mediated Release from Thermosensitive Liposomes
المؤلفون المشاركون
Moonen, Chrit T. W.
Derieppe, Marc
Escoffre, Jean-Michel
Denis de Senneville, Baudouin
van Houtum, Quincy
Rijbroek, Angelique Barten-van
van der Wurff-Jacobs, Kim
Dubois, Ludwig
Bos, Clemens
المصدر
Contrast Media & Molecular Imaging
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-03-07
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
In solid tumors, rapid local intravascular release of anticancer agents, e.g., doxorubicin (DOX), from thermosensitive liposomes (TSLs) can be an option to overcome poor extravasation of drug nanocarriers.
The driving force of DOX penetration is the drug concentration gradient between the vascular compartment and the tumor interstitium.
In this feasibility study, we used fibered confocal fluorescence microscopy (FCFM) to monitor in real-time DOX penetration in the interstitium of a subcutaneous tumor after its intravascular release from TSLs, Thermodox®.
Cell uptake kinetics of the released DOX was quantified, along with an in-depth assessment of released-DOX penetration using an evolution model.
A subcutaneous rat R1 rhabdomyosarcoma xenograft was used.
The rodent was positioned in a setup including a water bath, and FCFM identification of functional vessels in the tumor tissue was applied based on AngioSense.
The tumor-bearing leg was immersed in the 43°C water for preheating, and TSLs were injected intravenously.
Real-time monitoring of intratumoral (i.t.) DOX penetration could be performed, and it showed the progressing DOX wave front via its native fluorescence, labeling successively all cell nuclei.
Cell uptake rates (1/k) of 3 minutes were found (n=241 cells), and a released-DOX penetration in the range of 2500 µm2·s−1 was found in the tumor extravascular space.
This study also showed that not all vessels, identified as functional based on AngioSense, gave rise to local DOX penetration.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Derieppe, Marc& Escoffre, Jean-Michel& Denis de Senneville, Baudouin& van Houtum, Quincy& Rijbroek, Angelique Barten-van& van der Wurff-Jacobs, Kim…[et al.]. 2019. Assessment of Intratumoral Doxorubicin Penetration after Mild Hyperthermia-Mediated Release from Thermosensitive Liposomes. Contrast Media & Molecular Imaging،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1130187
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Derieppe, Marc…[et al.]. Assessment of Intratumoral Doxorubicin Penetration after Mild Hyperthermia-Mediated Release from Thermosensitive Liposomes. Contrast Media & Molecular Imaging No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1130187
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Derieppe, Marc& Escoffre, Jean-Michel& Denis de Senneville, Baudouin& van Houtum, Quincy& Rijbroek, Angelique Barten-van& van der Wurff-Jacobs, Kim…[et al.]. Assessment of Intratumoral Doxorubicin Penetration after Mild Hyperthermia-Mediated Release from Thermosensitive Liposomes. Contrast Media & Molecular Imaging. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1130187
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1130187
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر