Facile Fabrication of Composite Scaffolds for Long-Term Controlled Dual Drug Release
المؤلفون المشاركون
Li, Gang
Li, Dawei
Li, Chao
Wang, Xing
Li, Chunlin
Sun, Tunan
Zhou, Jin
المصدر
Advances in Polymer Technology
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-01-05
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Bone tuberculosis (TB) caused by mycobacterium tuberculosis continues to present a formidable challenge to humans.
To effectively cure serious bone TB, a novel kind of composite scaffolds with long-term dual drug release behaviours were prepared to satisfy the needs of both bone regeneration and antituberculosis drug therapy.
In virtue of an improved O/W emulsion technique, water-soluble isoniazid (INH)-loaded gelatin microparticles were obtained by tailoring the content of β-tricalcium phosphate (β-TCP), which played significant roles in INH entrapment efficiency and drug release behaviours.
By mixing with the poly(ε-caprolactone)-block-poly (lactic-co-glycolic acid) (b-PLGC) solution containing oil-soluble rifampicin (RFP) via the particle leaching combined with phase separation technique, the dual drugs-loaded composite scaffolds were fabricated, which possessed interconnected porous structures and achieved the steady release of INH and RFP drugs for three months.
Moreover, this dual drugs-loaded system could basically achieve their expectant roles of respective drugs without obvious influences with each other.
This strategy on preparation of intelligent composite scaffolds with the multi-drugs loading capacity and controlled long-term release behaviour will be potential and promising substrates in clinical treatment of bone tuberculosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Dawei& Li, Chao& Wang, Xing& Li, Chunlin& Sun, Tunan& Zhou, Jin…[et al.]. 2020. Facile Fabrication of Composite Scaffolds for Long-Term Controlled Dual Drug Release. Advances in Polymer Technology،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1130233
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Dawei…[et al.]. Facile Fabrication of Composite Scaffolds for Long-Term Controlled Dual Drug Release. Advances in Polymer Technology No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1130233
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Dawei& Li, Chao& Wang, Xing& Li, Chunlin& Sun, Tunan& Zhou, Jin…[et al.]. Facile Fabrication of Composite Scaffolds for Long-Term Controlled Dual Drug Release. Advances in Polymer Technology. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1130233
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1130233
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر