Facile Fabrication of Composite Scaffolds for Long-Term Controlled Dual Drug Release
Joint Authors
Li, Gang
Li, Dawei
Li, Chao
Wang, Xing
Li, Chunlin
Sun, Tunan
Zhou, Jin
Source
Advances in Polymer Technology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-05
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Bone tuberculosis (TB) caused by mycobacterium tuberculosis continues to present a formidable challenge to humans.
To effectively cure serious bone TB, a novel kind of composite scaffolds with long-term dual drug release behaviours were prepared to satisfy the needs of both bone regeneration and antituberculosis drug therapy.
In virtue of an improved O/W emulsion technique, water-soluble isoniazid (INH)-loaded gelatin microparticles were obtained by tailoring the content of β-tricalcium phosphate (β-TCP), which played significant roles in INH entrapment efficiency and drug release behaviours.
By mixing with the poly(ε-caprolactone)-block-poly (lactic-co-glycolic acid) (b-PLGC) solution containing oil-soluble rifampicin (RFP) via the particle leaching combined with phase separation technique, the dual drugs-loaded composite scaffolds were fabricated, which possessed interconnected porous structures and achieved the steady release of INH and RFP drugs for three months.
Moreover, this dual drugs-loaded system could basically achieve their expectant roles of respective drugs without obvious influences with each other.
This strategy on preparation of intelligent composite scaffolds with the multi-drugs loading capacity and controlled long-term release behaviour will be potential and promising substrates in clinical treatment of bone tuberculosis.
American Psychological Association (APA)
Li, Dawei& Li, Chao& Wang, Xing& Li, Chunlin& Sun, Tunan& Zhou, Jin…[et al.]. 2020. Facile Fabrication of Composite Scaffolds for Long-Term Controlled Dual Drug Release. Advances in Polymer Technology،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1130233
Modern Language Association (MLA)
Li, Dawei…[et al.]. Facile Fabrication of Composite Scaffolds for Long-Term Controlled Dual Drug Release. Advances in Polymer Technology No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1130233
American Medical Association (AMA)
Li, Dawei& Li, Chao& Wang, Xing& Li, Chunlin& Sun, Tunan& Zhou, Jin…[et al.]. Facile Fabrication of Composite Scaffolds for Long-Term Controlled Dual Drug Release. Advances in Polymer Technology. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1130233
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130233