Heterogeneous Enhancement Pattern in DCE-MRI Reveals the Morphology of Normal Lymph Nodes: An Experimental Study
المؤلفون المشاركون
Bontempi, Pietro
Busato, Alice
Conti, Giamaica
Della Sala, Sabino Walter
Marzola, Pasquina
Farace, Paolo
المصدر
Contrast Media & Molecular Imaging
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-04-04
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Purpose.
To investigate the heterogeneous enhancement pattern in normal lymph nodes of healthy mice by different albumin-binding contrast agents.
Methods.
The enhancement of normal lymph nodes was assessed in mice by dynamic contrast-enhanced MRI (DCE-MRI) after the administration of two contrast agents characterized by different albumin-binding properties: gadopentetate dimeglumine (Gd-DTPA) and gadobenate dimeglumine (Gd-BOPTA).
To take into account potential heterogeneities of the contrast uptake in the lymph nodes, k-means cluster analysis was performed on DCE-MRI data.
Cluster spatial distribution was visually assessed.
Statistical comparison among clusters and contrast agents was performed on semiquantitative parameters (AUC, wash-in rate, and wash-out rate) and on the relative size of the segmented clusters.
Results.
Cluster analysis of DCE-MRI data revealed at least two main clusters, localized in the outer portion and in the inner portion of each lymph node.
With both contrast agents, AUC (p<0.01) and wash-in (p<0.05) rates were greater in the inner cluster, which also showed a steeper wash-out rate than the outer cluster (Gd-BOPTA, p<0.01; Gd-DTPA, p=0.056).
The size of the outer cluster was greater than that of the inner cluster by Gd-DTPA (p<0.05) and Gd-BOPTA (p<0.01).
The enhancement pattern of Gd-DTPA was not significantly different from the enhancement pattern of Gd-BOPTA.
Conclusion.
DCE-MRI in normal lymph nodes shows a characteristic heterogeneous pattern, discriminating the periphery and the central portion of the lymph nodes.
Such a pattern deserves to be investigated as a diagnostic marker for lymph node staging.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bontempi, Pietro& Busato, Alice& Conti, Giamaica& Della Sala, Sabino Walter& Marzola, Pasquina& Farace, Paolo. 2019. Heterogeneous Enhancement Pattern in DCE-MRI Reveals the Morphology of Normal Lymph Nodes: An Experimental Study. Contrast Media & Molecular Imaging،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1130244
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bontempi, Pietro…[et al.]. Heterogeneous Enhancement Pattern in DCE-MRI Reveals the Morphology of Normal Lymph Nodes: An Experimental Study. Contrast Media & Molecular Imaging No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1130244
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bontempi, Pietro& Busato, Alice& Conti, Giamaica& Della Sala, Sabino Walter& Marzola, Pasquina& Farace, Paolo. Heterogeneous Enhancement Pattern in DCE-MRI Reveals the Morphology of Normal Lymph Nodes: An Experimental Study. Contrast Media & Molecular Imaging. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1130244
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1130244
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر