Heterogeneous Enhancement Pattern in DCE-MRI Reveals the Morphology of Normal Lymph Nodes: An Experimental Study
Joint Authors
Bontempi, Pietro
Busato, Alice
Conti, Giamaica
Della Sala, Sabino Walter
Marzola, Pasquina
Farace, Paolo
Source
Contrast Media & Molecular Imaging
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Purpose.
To investigate the heterogeneous enhancement pattern in normal lymph nodes of healthy mice by different albumin-binding contrast agents.
Methods.
The enhancement of normal lymph nodes was assessed in mice by dynamic contrast-enhanced MRI (DCE-MRI) after the administration of two contrast agents characterized by different albumin-binding properties: gadopentetate dimeglumine (Gd-DTPA) and gadobenate dimeglumine (Gd-BOPTA).
To take into account potential heterogeneities of the contrast uptake in the lymph nodes, k-means cluster analysis was performed on DCE-MRI data.
Cluster spatial distribution was visually assessed.
Statistical comparison among clusters and contrast agents was performed on semiquantitative parameters (AUC, wash-in rate, and wash-out rate) and on the relative size of the segmented clusters.
Results.
Cluster analysis of DCE-MRI data revealed at least two main clusters, localized in the outer portion and in the inner portion of each lymph node.
With both contrast agents, AUC (p<0.01) and wash-in (p<0.05) rates were greater in the inner cluster, which also showed a steeper wash-out rate than the outer cluster (Gd-BOPTA, p<0.01; Gd-DTPA, p=0.056).
The size of the outer cluster was greater than that of the inner cluster by Gd-DTPA (p<0.05) and Gd-BOPTA (p<0.01).
The enhancement pattern of Gd-DTPA was not significantly different from the enhancement pattern of Gd-BOPTA.
Conclusion.
DCE-MRI in normal lymph nodes shows a characteristic heterogeneous pattern, discriminating the periphery and the central portion of the lymph nodes.
Such a pattern deserves to be investigated as a diagnostic marker for lymph node staging.
American Psychological Association (APA)
Bontempi, Pietro& Busato, Alice& Conti, Giamaica& Della Sala, Sabino Walter& Marzola, Pasquina& Farace, Paolo. 2019. Heterogeneous Enhancement Pattern in DCE-MRI Reveals the Morphology of Normal Lymph Nodes: An Experimental Study. Contrast Media & Molecular Imaging،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1130244
Modern Language Association (MLA)
Bontempi, Pietro…[et al.]. Heterogeneous Enhancement Pattern in DCE-MRI Reveals the Morphology of Normal Lymph Nodes: An Experimental Study. Contrast Media & Molecular Imaging No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1130244
American Medical Association (AMA)
Bontempi, Pietro& Busato, Alice& Conti, Giamaica& Della Sala, Sabino Walter& Marzola, Pasquina& Farace, Paolo. Heterogeneous Enhancement Pattern in DCE-MRI Reveals the Morphology of Normal Lymph Nodes: An Experimental Study. Contrast Media & Molecular Imaging. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1130244
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130244