Neutrophil Elastase Activity Imaging: Recent Approaches in the Design and Applications of Activity-Based Probes and Substrate-Based Probes
المؤلفون المشاركون
Jugniot, Natacha
Voisin, Pierre
Bentaher, Abderrazzak
Mellet, Philippe
المصدر
Contrast Media & Molecular Imaging
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-06-12
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
The last few decades of protease research has confirmed that a number of important biological processes are strictly dependent on proteolysis.
Neutrophil elastase (NE) is a critical protease in immune response and host defense mechanisms in both physiological and disease-associated conditions.
Particularly, NE has been identified as a promising biomarker for early diagnosis of lung inflammation.
Recent studies have shown an increasing interest in developing methods for NE activity imaging both in vitro and in vivo.
Unlike anatomical imaging modalities, functional molecular imaging, including enzymatic activities, enables disease detection at a very early stage and thus constitutes a much more accurate approach.
When combined with advanced imaging technologies, opportunities arise for measuring imbalanced proteolytic activities with unprecedented details.
Such technologies consist in building the highest resolved and sensitive instruments as well as the most specific probes based either on peptide substrates or on covalent inhibitors.
This review outlines strengths and weaknesses of these technologies and discuss their applications to investigate NE activity as biomarker of pulmonary inflammatory diseases by imaging.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jugniot, Natacha& Voisin, Pierre& Bentaher, Abderrazzak& Mellet, Philippe. 2019. Neutrophil Elastase Activity Imaging: Recent Approaches in the Design and Applications of Activity-Based Probes and Substrate-Based Probes. Contrast Media & Molecular Imaging،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1130342
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jugniot, Natacha…[et al.]. Neutrophil Elastase Activity Imaging: Recent Approaches in the Design and Applications of Activity-Based Probes and Substrate-Based Probes. Contrast Media & Molecular Imaging No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1130342
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jugniot, Natacha& Voisin, Pierre& Bentaher, Abderrazzak& Mellet, Philippe. Neutrophil Elastase Activity Imaging: Recent Approaches in the Design and Applications of Activity-Based Probes and Substrate-Based Probes. Contrast Media & Molecular Imaging. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1130342
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1130342
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر