Neutrophil Elastase Activity Imaging: Recent Approaches in the Design and Applications of Activity-Based Probes and Substrate-Based Probes
Joint Authors
Jugniot, Natacha
Voisin, Pierre
Bentaher, Abderrazzak
Mellet, Philippe
Source
Contrast Media & Molecular Imaging
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-12
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The last few decades of protease research has confirmed that a number of important biological processes are strictly dependent on proteolysis.
Neutrophil elastase (NE) is a critical protease in immune response and host defense mechanisms in both physiological and disease-associated conditions.
Particularly, NE has been identified as a promising biomarker for early diagnosis of lung inflammation.
Recent studies have shown an increasing interest in developing methods for NE activity imaging both in vitro and in vivo.
Unlike anatomical imaging modalities, functional molecular imaging, including enzymatic activities, enables disease detection at a very early stage and thus constitutes a much more accurate approach.
When combined with advanced imaging technologies, opportunities arise for measuring imbalanced proteolytic activities with unprecedented details.
Such technologies consist in building the highest resolved and sensitive instruments as well as the most specific probes based either on peptide substrates or on covalent inhibitors.
This review outlines strengths and weaknesses of these technologies and discuss their applications to investigate NE activity as biomarker of pulmonary inflammatory diseases by imaging.
American Psychological Association (APA)
Jugniot, Natacha& Voisin, Pierre& Bentaher, Abderrazzak& Mellet, Philippe. 2019. Neutrophil Elastase Activity Imaging: Recent Approaches in the Design and Applications of Activity-Based Probes and Substrate-Based Probes. Contrast Media & Molecular Imaging،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1130342
Modern Language Association (MLA)
Jugniot, Natacha…[et al.]. Neutrophil Elastase Activity Imaging: Recent Approaches in the Design and Applications of Activity-Based Probes and Substrate-Based Probes. Contrast Media & Molecular Imaging No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1130342
American Medical Association (AMA)
Jugniot, Natacha& Voisin, Pierre& Bentaher, Abderrazzak& Mellet, Philippe. Neutrophil Elastase Activity Imaging: Recent Approaches in the Design and Applications of Activity-Based Probes and Substrate-Based Probes. Contrast Media & Molecular Imaging. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1130342
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130342