Allergic Rhinitis in Rats Is Associated with an Inflammatory Response of the Hippocampus
المؤلفون المشاركون
Yang, Shasha
Wu, Jing
Zhang, Qinxiu
Li, Xinrong
Liu, Daien
Zeng, Bin
Liu, Zhiqing
Kang, Haoran
Zhong, Zhendong
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-16
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Allergic rhinitis (AR) is a major concern in personal and public health, which negatively affects emotions and behavior, leading to cognitive deficits, memory decline, poor school performance, anxiety, and depression.
Several cellular and molecular mediators are released in the inflammatory process of AR and activate common neuroimmune mechanisms, involving emotionally relevant circuits and the induction of anxiety.
Responsiveness of the hypothalamic-pituitary-adrenal (HPA) axis to allergic processes have been reported, which may also include responsiveness of the hippocampus, cortex, and other brain regions.
Here, we have used an optimized rat model of AR to explore whether the disease has a relationship with inflammatory responses in the hippocampus.
AR was established in adult rats by ovalbumin sensitization, and the expression of various inflammatory substances in the hippocampus was measured by specific assays.
Comparison between experimental and various control groups of animals revealed an association of AR with significant upregulation of substance P, microglia surface antigen (CD11b), glial fibrillary acid protein (GFAP), tumor necrosis factor-α (TNF-α), and interleukin 6 (IL-6) in the hippocampus.
Thus, we hypothesize that the AR challenge may activate these inflammatory mediators in the hippocampus, which in turn contribute to the abnormal behavior and neurological deficits associated with AR.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yang, Shasha& Wu, Jing& Zhang, Qinxiu& Li, Xinrong& Liu, Daien& Zeng, Bin…[et al.]. 2018. Allergic Rhinitis in Rats Is Associated with an Inflammatory Response of the Hippocampus. Behavioural Neurology،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1130367
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yang, Shasha…[et al.]. Allergic Rhinitis in Rats Is Associated with an Inflammatory Response of the Hippocampus. Behavioural Neurology No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1130367
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yang, Shasha& Wu, Jing& Zhang, Qinxiu& Li, Xinrong& Liu, Daien& Zeng, Bin…[et al.]. Allergic Rhinitis in Rats Is Associated with an Inflammatory Response of the Hippocampus. Behavioural Neurology. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1130367
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1130367
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر