Allergic Rhinitis in Rats Is Associated with an Inflammatory Response of the Hippocampus
Joint Authors
Yang, Shasha
Wu, Jing
Zhang, Qinxiu
Li, Xinrong
Liu, Daien
Zeng, Bin
Liu, Zhiqing
Kang, Haoran
Zhong, Zhendong
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Allergic rhinitis (AR) is a major concern in personal and public health, which negatively affects emotions and behavior, leading to cognitive deficits, memory decline, poor school performance, anxiety, and depression.
Several cellular and molecular mediators are released in the inflammatory process of AR and activate common neuroimmune mechanisms, involving emotionally relevant circuits and the induction of anxiety.
Responsiveness of the hypothalamic-pituitary-adrenal (HPA) axis to allergic processes have been reported, which may also include responsiveness of the hippocampus, cortex, and other brain regions.
Here, we have used an optimized rat model of AR to explore whether the disease has a relationship with inflammatory responses in the hippocampus.
AR was established in adult rats by ovalbumin sensitization, and the expression of various inflammatory substances in the hippocampus was measured by specific assays.
Comparison between experimental and various control groups of animals revealed an association of AR with significant upregulation of substance P, microglia surface antigen (CD11b), glial fibrillary acid protein (GFAP), tumor necrosis factor-α (TNF-α), and interleukin 6 (IL-6) in the hippocampus.
Thus, we hypothesize that the AR challenge may activate these inflammatory mediators in the hippocampus, which in turn contribute to the abnormal behavior and neurological deficits associated with AR.
American Psychological Association (APA)
Yang, Shasha& Wu, Jing& Zhang, Qinxiu& Li, Xinrong& Liu, Daien& Zeng, Bin…[et al.]. 2018. Allergic Rhinitis in Rats Is Associated with an Inflammatory Response of the Hippocampus. Behavioural Neurology،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1130367
Modern Language Association (MLA)
Yang, Shasha…[et al.]. Allergic Rhinitis in Rats Is Associated with an Inflammatory Response of the Hippocampus. Behavioural Neurology No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1130367
American Medical Association (AMA)
Yang, Shasha& Wu, Jing& Zhang, Qinxiu& Li, Xinrong& Liu, Daien& Zeng, Bin…[et al.]. Allergic Rhinitis in Rats Is Associated with an Inflammatory Response of the Hippocampus. Behavioural Neurology. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1130367
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130367